{"id":"W2907596629","doi":"10.3390/v11010017","title":"Genomic-Scale Interaction Involving Complementary Sequences in the Hepatitis C Virus 5′UTR Domain IIa and the RNA-Dependent RNA Polymerase Coding Region Promotes Efficient Virus Replication","year":2018,"lang":"en","type":"article","venue":"Viruses","topic":"Hepatitis C virus research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"NS5B; Internal ribosome entry site; RNA; RNA-dependent RNA polymerase; Biology; RNA polymerase; Virology; Untranslated region; Viral replication; Molecular biology; Hepatitis C virus; Virus; Genetics; Gene; Ribosome; Hepacivirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002364623,0.0002244694,0.0002091119,0.0001617184,0.0001735744,0.0003573215,0.0001554665,0.0001977225,0.001733118],"category_scores_gemma":[0.0003176729,0.0001861922,0.0001823263,0.0001082595,0.0002540343,0.0001286442,0.0003152926,0.0003361856,0.000563868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003454082,"about_ca_system_score_gemma":0.0002408143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003535796,"about_ca_topic_score_gemma":0.001016213,"domain_scores_codex":[0.9997483,0.00005798638,0.00001424624,0.00005539503,0.00007824172,0.00004577852],"domain_scores_gemma":[0.9998374,0.00005605482,0.00003408386,0.00001973003,0.00001178983,0.00004095981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002927373,0.00002457729,0.0001427258,0.00001276011,0.000003139326,0.00001350205,0.000003731311,0.00006296209,0.9989761,0.00006742663,0.00001352069,0.0006504044],"study_design_scores_gemma":[0.0000108809,0.0002134398,0.004704784,0.000006280742,0.00001641599,0.0001787579,0.00001887405,0.001672407,0.9915949,0.00004397469,0.001535059,0.000004233033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940125,0.0007139444,0.002798629,0.00003755714,0.00001872284,0.00002223253,0.00005858474,0.00006372414,0.002274174],"genre_scores_gemma":[0.9966683,0.0001499902,0.00220447,0.0000251206,0.000005696225,0.000009963168,0.000171671,0.00001149584,0.0007534202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001733118,"threshold_uncertainty_score":0.005797863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06325354093822072,"score_gpt":0.3459655905849429,"score_spread":0.2827120496467222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}