{"id":"W2907596629","doi":"10.3390/v11010017","title":"Genomic-Scale Interaction Involving Complementary Sequences in the Hepatitis C Virus 5′UTR Domain IIa and the RNA-Dependent RNA Polymerase Coding Region Promotes Efficient Virus Replication","year":2018,"lang":"en","type":"article","venue":"Viruses","topic":"Hepatitis C virus research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"NS5B; Internal ribosome entry site; RNA; RNA-dependent RNA polymerase; Biology; RNA polymerase; Virology; Untranslated region; Viral replication; Molecular biology; Hepatitis C virus; Virus; Genetics; Gene; Ribosome; Hepacivirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001812518,0.0002300857,0.0003233638,0.0002567276,0.0005474381,0.0001806327,0.0003265511,0.00007783499,0.0001499658],"category_scores_gemma":[0.0003135174,0.0001458586,0.00007000035,0.0003878223,0.0006712443,0.0002340487,0.0002078504,0.000403835,0.00006438346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236679,"about_ca_system_score_gemma":0.0001001383,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.0459139,"about_ca_topic_score_gemma":0.02389591,"domain_scores_codex":[0.9970946,0.0007202363,0.0005790336,0.0005685835,0.000618667,0.0004188565],"domain_scores_gemma":[0.9982198,0.0005402018,0.0002299686,0.0007851587,0.0001178734,0.0001069218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001423075,0.0003773938,0.1366666,0.0001048812,0.0001175546,0.000122299,0.01554137,0.00001027017,0.8135208,0.001431814,0.001338209,0.02934571],"study_design_scores_gemma":[0.009149273,0.00157169,0.1563082,0.001154982,0.0002522068,0.0004298745,0.007644495,0.01560582,0.790359,0.001569364,0.01509837,0.0008567584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929591,0.0009414861,0.0003390037,0.002898924,0.0002114192,0.001542125,0.00004286164,0.00006014444,0.001004926],"genre_scores_gemma":[0.9944885,0.001888188,0.0002780999,0.002681799,0.0003637775,0.0002031974,0.00002932506,0.00003185766,0.00003528353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02848895,"threshold_uncertainty_score":0.9939154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06325354093822072,"score_gpt":0.3459655905849429,"score_spread":0.2827120496467222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}