{"id":"W2907667408","doi":"10.3390/ph12010003","title":"Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia","year":2019,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Probe Development and Commercialization; University of Alberta","funders":"Alberta Innovates - Health Solutions","keywords":"Tirapazamine; Chemistry; Medicine; Medical physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007573764,0.0003219792,0.0005324472,0.0001539837,0.00005651919,0.00001423389,0.0002903422,0.0001726155,0.00005861678],"category_scores_gemma":[0.00003808031,0.0003170796,0.0001280919,0.0002605297,0.000164886,0.00001163269,0.000123803,0.0001316484,0.000009738871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000378223,"about_ca_system_score_gemma":0.0001209676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005997301,"about_ca_topic_score_gemma":0.000005048937,"domain_scores_codex":[0.9977728,0.00006439597,0.0007791884,0.0006189838,0.000283895,0.000480699],"domain_scores_gemma":[0.998921,0.0000991078,0.0002393067,0.0004044757,0.0001590641,0.0001770434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007886436,0.000467523,0.0006162671,0.0008384064,0.0002253348,4.096284e-7,0.0001078019,0.0001098681,0.9467637,0.0004686883,0.0001306215,0.04948276],"study_design_scores_gemma":[0.006910957,0.0001075245,0.003102766,0.0001011388,0.0001924721,0.000003378539,0.00008003305,0.005031994,0.7958927,0.00005891833,0.1881457,0.0003724631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684608,0.006669553,0.0210081,0.000216497,0.0004078891,0.00246512,0.0001284827,0.00002251949,0.0006210646],"genre_scores_gemma":[0.9851305,0.001383469,0.01207012,0.0004477007,0.0001387298,0.000328207,0.0001662555,0.00005120173,0.0002838435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1880151,"threshold_uncertainty_score":0.9999281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03122670344087372,"score_gpt":0.3361827302718156,"score_spread":0.3049560268309418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}