{"id":"W2907667408","doi":"10.3390/ph12010003","title":"Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia","year":2019,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Probe Development and Commercialization; University of Alberta","funders":"Alberta Innovates - Health Solutions","keywords":"Tirapazamine; Chemistry; Medicine; Medical physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885062,0.0003309153,0.0001578253,0.0001358691,0.00006860614,0.0002125936,0.0004270491,0.0004438154,0.0009915238],"category_scores_gemma":[0.0001362455,0.0001881396,0.0001993946,0.0001130219,0.000200981,0.0002456354,0.0001816629,0.0003409789,0.0004210789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002491242,"about_ca_system_score_gemma":0.0002810173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004986463,"about_ca_topic_score_gemma":0.0004468251,"domain_scores_codex":[0.9999367,0.000008940198,0.000003665273,0.00001976781,0.00001759167,0.00001319532],"domain_scores_gemma":[0.9999437,0.000005946883,0.00002217665,0.000004370957,0.000008873936,0.0000149355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009078941,0.00002427077,0.00008732407,0.00005407776,0.000004937437,0.00005427196,0.000008321907,0.0001949976,0.996776,0.0002380697,0.00003899668,0.002427827],"study_design_scores_gemma":[0.0000559159,0.0006921983,0.0007859864,0.000004347947,0.00001508527,0.0003868801,0.000005484246,0.0007864569,0.9927703,0.00003991455,0.004451642,0.00000586473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.942817,0.007981048,0.03978954,0.0003338344,0.00006597483,0.0004846245,0.0005238524,0.0002032086,0.007800882],"genre_scores_gemma":[0.9562661,0.004634551,0.03135128,0.0001659226,0.00003277567,0.0002617305,0.00106084,0.00003183565,0.00619504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009915238,"threshold_uncertainty_score":0.003316998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03122670344087372,"score_gpt":0.3361827302718156,"score_spread":0.3049560268309418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}