{"id":"W2907801376","doi":"10.1016/j.cjca.2018.12.029","title":"Functional Dosage of Muscarinic Cholinergic Receptor 3 Signalling, Not the Gene Dose, Determines Its Hypertension Pathogenesis","year":2018,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Medicine; Muscarinic acetylcholine receptor; Cholinergic; Pathogenesis; Pharmacology; Signalling; Receptor; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004121485,0.0003869046,0.0005240691,0.0008091088,0.0002552665,0.0005053477,0.0003836897,0.0007710547,0.003270219],"category_scores_gemma":[0.0008633927,0.0002326791,0.0003729684,0.0003227653,0.0007664067,0.000361809,0.0002895998,0.0007169354,0.0003970567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001605999,"about_ca_system_score_gemma":0.0002224223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000472776,"about_ca_topic_score_gemma":0.0005568826,"domain_scores_codex":[0.9994722,0.000149255,0.00005249547,0.0001383808,0.0001201797,0.00006747446],"domain_scores_gemma":[0.9991037,0.0003480687,0.0001828492,0.0001516856,0.00005978797,0.000153912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001055416,0.00007961936,0.01394436,0.00005911513,0.0000887639,0.0008770555,0.0001230464,0.00005283528,0.97688,0.001104829,0.0001417135,0.005593237],"study_design_scores_gemma":[0.0002229363,0.001325586,0.5503483,0.00009379906,0.001096596,0.01427409,0.0007057831,0.002183243,0.4209856,0.004161701,0.004520138,0.00008217935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938545,0.00120293,0.002420824,0.0003683335,0.00006965271,0.00001291317,0.0002970456,0.00006390821,0.001709804],"genre_scores_gemma":[0.9971761,0.0005094868,0.0009532708,0.0001093733,0.00003691328,0.00001151204,0.0001132134,0.00005311752,0.001036944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003270219,"threshold_uncertainty_score":0.01093996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05309746575457414,"score_gpt":0.2491717977915292,"score_spread":0.1960743320369551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}