{"id":"W2907881473","doi":"10.1016/j.clgc.2018.12.009","title":"Impact of Addition of Metformin to Abiraterone in Metastatic Castration-Resistant Prostate Cancer Patients With Disease Progressing While Receiving Abiraterone Treatment (MetAb-Pro): Phase 2 Pilot Study","year":2019,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"Janssen Biotech; Orionin Tutkimussäätiö; Cilag; Astellas Pharma; Eisai; Sanofi; F. Hoffmann-La Roche; Roche; Novartis; British Microcirculation Society; Amgen; Pfizer; Bristol-Myers Squibb; International Parkinson and Movement Disorder Society; Bayer","keywords":"Medicine; Abiraterone; Prostate cancer; Metformin; Abiraterone acetate; Oncology; Internal medicine; Disease; Cancer; Androgen deprivation therapy; Insulin; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001512808,0.001901001,0.002313548,0.0005954825,0.0005392071,0.001391349,0.001119457,0.001397775,0.003503703],"category_scores_gemma":[0.001688649,0.0007360833,0.002012812,0.0005855804,0.001365421,0.001354518,0.0006179903,0.003739445,0.0006023398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008692548,"about_ca_system_score_gemma":0.002315689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002318404,"about_ca_topic_score_gemma":0.005802155,"domain_scores_codex":[0.9993321,0.0003359369,0.00003703132,0.0001092584,0.0000495678,0.0001360398],"domain_scores_gemma":[0.9987013,0.0002581339,0.0002305157,0.0001055372,0.00006258145,0.0006418616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8824379,0.06426144,0.002634832,0.0002545927,0.0007222039,0.0001041969,0.0001858481,0.00111697,0.009894953,0.00008425156,0.0006785216,0.03762426],"study_design_scores_gemma":[0.339203,0.6487056,0.008381554,0.00002400556,0.00056721,0.00008817003,0.00008808815,0.0005416889,0.001505661,0.0001053953,0.0007552732,0.00003439979],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974102,0.0007022094,0.0001199661,0.0001967948,0.00008183497,0.0006242421,0.0003275138,0.00003824081,0.00049905],"genre_scores_gemma":[0.9944311,0.001123806,0.0009144712,0.0003969402,0.0002525876,0.0008379088,0.0008362316,0.00002234334,0.001184634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003503703,"threshold_uncertainty_score":0.01172107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05126263416340064,"score_gpt":0.390758920553869,"score_spread":0.3394962863904683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}