{"id":"W2907881473","doi":"10.1016/j.clgc.2018.12.009","title":"Impact of Addition of Metformin to Abiraterone in Metastatic Castration-Resistant Prostate Cancer Patients With Disease Progressing While Receiving Abiraterone Treatment (MetAb-Pro): Phase 2 Pilot Study","year":2019,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"Janssen Biotech; Orionin Tutkimussäätiö; Cilag; Astellas Pharma; Eisai; Sanofi; F. Hoffmann-La Roche; Roche; Novartis; British Microcirculation Society; Amgen; Pfizer; Bristol-Myers Squibb; International Parkinson and Movement Disorder Society; Bayer","keywords":"Medicine; Abiraterone; Prostate cancer; Metformin; Abiraterone acetate; Oncology; Internal medicine; Disease; Cancer; Androgen deprivation therapy; Insulin; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003199205,0.0003266035,0.0006833529,0.0001063562,0.00004241489,0.00002290345,0.0001605068,0.00004716433,0.0002253324],"category_scores_gemma":[0.00004292074,0.0002363157,0.0001419793,0.0002623765,0.00009420842,0.00003678693,0.00006395962,0.0001019928,0.000003198722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001372669,"about_ca_system_score_gemma":0.0007573182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000501869,"about_ca_topic_score_gemma":0.0006085495,"domain_scores_codex":[0.9974858,0.0002679688,0.0009395475,0.0006270555,0.0003023267,0.0003773476],"domain_scores_gemma":[0.9984417,0.00003661949,0.0005058918,0.0004708187,0.0002982832,0.0002466779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02146535,0.01456266,0.7648575,0.0002176411,0.0008968971,0.00001939015,0.0003635198,0.002297665,0.04318007,4.801515e-7,0.000145858,0.151993],"study_design_scores_gemma":[0.01774902,0.05586702,0.9084397,0.0003629846,0.000498755,4.417518e-7,0.0001670068,0.0000574164,0.01538354,0.000006380401,0.000955523,0.0005122299],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814664,0.01484474,0.000005856627,0.000008185277,0.000235894,0.002351352,0.001068073,0.000007492694,0.00001198936],"genre_scores_gemma":[0.9955657,0.002665181,0.0002671928,0.00002984653,0.0001684269,0.000903993,0.0002491131,0.00004714431,0.0001034114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1514808,"threshold_uncertainty_score":0.9636675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05126263416340064,"score_gpt":0.390758920553869,"score_spread":0.3394962863904683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}