{"id":"W2907888026","doi":"10.3389/fnmol.2018.00495","title":"Fragile-X Syndrome Is Associated With NMDA Receptor Hypofunction and Reduced Dendritic Complexity in Mature Dentate Granule Cells","year":2019,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; International Brain Research Organization; Michael Smith Health Research BC","keywords":"Dentate gyrus; AMPA receptor; FMR1; NMDA receptor; Neuroscience; Hippocampal formation; Fragile X syndrome; Granule cell; Neurogenesis; Glutamate receptor; Biology; Dendritic spine; Cell biology; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005161317,0.0005811966,0.0002465415,0.0004190743,0.0001192856,0.0001336857,0.0001466346,0.0003644078,0.001270125],"category_scores_gemma":[0.0001282741,0.0001445514,0.0001807042,0.0001514599,0.0002115135,0.0001376606,0.0002369534,0.0003322227,0.0002247163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001552122,"about_ca_system_score_gemma":0.0000924043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112107,"about_ca_topic_score_gemma":0.001322591,"domain_scores_codex":[0.9999224,0.000005036426,0.00001106597,0.00003022144,0.00002170378,0.000009573476],"domain_scores_gemma":[0.9998598,0.000008685766,0.00008814142,0.000006901196,0.000006993421,0.0000294507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002176458,0.00002333014,0.005823418,0.00005200753,0.00003056327,0.002699944,0.00004041927,0.00004147865,0.9884462,0.00008388529,0.000110619,0.002430489],"study_design_scores_gemma":[0.00009797736,0.0006896498,0.7278256,0.00005025955,0.0001511035,0.05383075,0.0001489374,0.0009541136,0.2115864,0.0004017826,0.004232695,0.00003085712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975147,0.0007358487,0.0008724318,0.00004426372,0.00001065112,0.000007388644,0.0003780646,0.00007066924,0.0003658949],"genre_scores_gemma":[0.9966935,0.0008619729,0.0009806164,0.00004071452,0.00001263705,0.00001552175,0.0004712107,0.00001442945,0.0009095105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270125,"threshold_uncertainty_score":0.004248977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007773468579282673,"score_gpt":0.2025553244312759,"score_spread":0.1947818558519932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}