{"id":"W2907888026","doi":"10.3389/fnmol.2018.00495","title":"Fragile-X Syndrome Is Associated With NMDA Receptor Hypofunction and Reduced Dendritic Complexity in Mature Dentate Granule Cells","year":2019,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; International Brain Research Organization; Michael Smith Health Research BC","keywords":"Dentate gyrus; AMPA receptor; FMR1; NMDA receptor; Neuroscience; Hippocampal formation; Fragile X syndrome; Granule cell; Neurogenesis; Glutamate receptor; Biology; Dendritic spine; Cell biology; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203074,0.0002000549,0.000196926,0.0001253571,0.00005621417,0.00004798736,0.0002288104,0.0001113198,0.00000753287],"category_scores_gemma":[0.00003256439,0.0002048858,0.00002902349,0.000370281,0.0001945876,0.0000118933,0.0001126189,0.0001804539,0.00000365854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002962738,"about_ca_system_score_gemma":0.00005075804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001668585,"about_ca_topic_score_gemma":0.00002383625,"domain_scores_codex":[0.9984202,0.00009576469,0.0001902123,0.0006928812,0.0002369938,0.0003639907],"domain_scores_gemma":[0.9995707,0.000004355262,0.00007172202,0.0002463871,0.00002333093,0.00008349306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004794879,0.00006959413,0.02653575,0.00001412924,0.000004542368,0.00002886306,0.00004533014,0.000294242,0.9723197,0.000003499083,0.0005326738,0.000103746],"study_design_scores_gemma":[0.002228974,0.0007810534,0.4684965,0.00008846669,0.00001132,0.00004773875,0.0002031568,0.001406056,0.5244211,0.0002101244,0.001421924,0.0006836124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977381,0.0001683549,0.000834421,0.00008883981,0.0006654525,0.0003760468,0.00002496317,0.000008901989,0.00009491048],"genre_scores_gemma":[0.9967672,0.000167179,0.001681406,0.001085188,0.000001962852,0.0000162543,0.00004628233,0.00002631319,0.0002081971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4478986,"threshold_uncertainty_score":0.8355002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007773468579282673,"score_gpt":0.2025553244312759,"score_spread":0.1947818558519932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}