{"id":"W2907895283","doi":"10.3390/genes10010017","title":"Alternative Biochemistries for Alien Life: Basic Concepts and Requirements for the Design of a Robust Biocontainment System in Genetic Isolation","year":2018,"lang":"en","type":"review","venue":"Genes","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Genetic code; Synthetic biology; Organism; Biology; Isolation (microbiology); Computer science; Computational biology; Genetics; Gene; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002831639,0.0002418555,0.0004468455,0.00004350087,0.00005208376,0.00001797271,0.0001906813,0.0001699323,9.391516e-7],"category_scores_gemma":[0.00006610337,0.0001808142,0.0001332913,0.00005619897,0.00007877925,0.000001653595,0.00007407297,0.00002883071,2.694272e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003096036,"about_ca_system_score_gemma":0.0001098658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001129218,"about_ca_topic_score_gemma":0.000005538284,"domain_scores_codex":[0.9989202,0.00003960597,0.0004157541,0.0003574673,0.00007647154,0.0001904764],"domain_scores_gemma":[0.9992996,0.00008896133,0.000223939,0.0002634432,0.00008485413,0.00003919366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004184174,0.0001183233,0.0001425612,0.06374328,0.002326049,0.000001933394,0.0004603739,0.01030602,0.03982703,0.0001256627,0.002056743,0.8804736],"study_design_scores_gemma":[0.002340237,0.001364776,0.00003781794,0.005617769,0.001473817,0.00002631312,0.0005270285,0.009934806,0.1076529,0.00003149019,0.8699666,0.001026479],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002935221,0.7140164,0.2837675,0.000003337734,0.0001279094,0.001686601,0.00009889601,0.00000322694,0.000002639999],"genre_scores_gemma":[0.00595036,0.9862493,0.005990863,0.000008713216,0.000406191,0.001153726,0.0001488256,0.00004126292,0.00005072169],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8794471,"threshold_uncertainty_score":0.7373388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06040738796236684,"score_gpt":0.3649476786675647,"score_spread":0.3045402907051978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}