{"id":"W2907903894","doi":"10.1111/acel.12889","title":"Circumventing senescence is associated with stem cell properties and metformin sensitivity","year":2019,"lang":"en","type":"article","venue":"Aging Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Institute of Cancer Research; International Development Research Centre; Cancer Research Society; National Cancer Institute; Foundation for the National Institutes of Health","keywords":"Biology; Senescence; Stem cell; Cancer research; Cell biology; Carcinogenesis; Cancer stem cell; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004032014,0.0002164392,0.000377559,0.00008660971,0.0001125891,0.00004766174,0.0000544845,0.00007890421,0.00002649232],"category_scores_gemma":[0.00001540198,0.0001663158,0.00005114079,0.0002212227,0.00007667447,0.0001750365,0.00005657716,0.0002365542,0.00006087447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005953018,"about_ca_system_score_gemma":0.00009037304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000218632,"about_ca_topic_score_gemma":0.00002231468,"domain_scores_codex":[0.9985738,0.00007150003,0.0002051626,0.0004207535,0.0003229387,0.0004058483],"domain_scores_gemma":[0.9992105,0.0001022349,0.0001373448,0.0003004446,0.0001156991,0.0001337147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006701275,0.0001700161,0.4579793,0.0007302276,0.00005107253,0.0002884381,0.00397565,0.000006344261,0.5311742,0.000004384205,0.0001522772,0.005401059],"study_design_scores_gemma":[0.002458897,0.0002975736,0.0792866,0.001332606,0.0002070667,0.0002304984,0.003281333,0.003632333,0.9075744,0.00000506591,0.001090828,0.0006028623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960788,0.0007355722,0.00008177667,0.0001687714,0.00009410542,0.0003603201,0.000004263592,0.0001235619,0.002352842],"genre_scores_gemma":[0.9908261,0.00006369747,0.0001888052,0.0005013056,0.000039705,0.000003225225,0.000006512896,0.00003531218,0.008335295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3786927,"threshold_uncertainty_score":0.6782161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02028926204902963,"score_gpt":0.2055713243335672,"score_spread":0.1852820622845376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}