{"id":"W2907917440","doi":"10.1186/s13148-018-0606-9","title":"Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci","year":2019,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"European Research Council; Sigrid Juséliuksen Säätiö; Canadian Institutes of Health Research; Helsingin Yliopiston Tiedesäätiö; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Academy of Finland","keywords":"Cotinine; DNA methylation; Epigenetics; CpG site; Methylation; Epigenome; Single-nucleotide polymorphism; Nicotine; Biology; Genetics; Genome-wide association study; Biomarker; Genotype; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001831334,0.0002902073,0.0006559289,0.0001078617,0.0000417088,0.00002320121,0.00041612,0.0004446468,0.00006146332],"category_scores_gemma":[0.002004182,0.0003034378,0.0002241213,0.0002805443,0.00007921761,0.000004681207,0.0002807672,0.0003653701,0.00004029174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006613689,"about_ca_system_score_gemma":0.0001681816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002290229,"about_ca_topic_score_gemma":0.0001714674,"domain_scores_codex":[0.9961011,0.0004242358,0.001732341,0.0007745776,0.0004808052,0.000486944],"domain_scores_gemma":[0.9973972,0.000519334,0.0007102706,0.000797988,0.0003793211,0.0001958153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000650733,0.001512576,0.9689823,0.00003570036,0.00009072242,9.0233e-7,0.00009771383,0.003910782,0.02067938,0.00002144579,0.00006820644,0.004535195],"study_design_scores_gemma":[0.002973785,0.002431557,0.982547,0.00003308553,0.00006446288,5.951619e-8,0.0001210501,0.0004039917,0.005744101,0.0001962558,0.005133901,0.0003506798],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946346,0.001578972,0.001398329,0.0001307737,0.0007663196,0.001000216,0.00005395401,0.00001119473,0.0004255988],"genre_scores_gemma":[0.9956538,0.002170924,0.001272698,0.0001436482,0.0002580152,0.00002059923,0.00007621406,0.00005167786,0.0003524281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01493527,"threshold_uncertainty_score":0.9999418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03549484570916981,"score_gpt":0.3511567114975077,"score_spread":0.3156618657883378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}