{"id":"W2907984739","doi":"10.1016/j.cell.2018.11.038","title":"METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Deutsche Forschungsgemeinschaft; National Cancer Institute; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; American Association for Cancer Research; Neuroendocrine Tumor Research Foundation; Chemistry, Engineering and Medicine for Human Health, Stanford University; Cancer Prevention and Research Institute of Texas","keywords":"Biology; Carcinogenesis; Cancer research; Methylation; Downregulation and upregulation; Pancreatic cancer; Methyltransferase; Protein biosynthesis; Signal transduction; Cancer; Cell biology; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002029227,0.00009962573,0.0001235864,0.00005976171,0.00002291316,0.000008038173,0.00009878518,0.00008656597,0.00006628313],"category_scores_gemma":[0.00003096524,0.0000985825,0.00007644031,0.0001041276,0.00001338642,0.000003232564,0.00002867883,0.00003022453,0.00004283831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005446645,"about_ca_system_score_gemma":0.00005082827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003196317,"about_ca_topic_score_gemma":0.000008823476,"domain_scores_codex":[0.9992418,0.00004558881,0.000203694,0.0002372423,0.0001502633,0.0001213844],"domain_scores_gemma":[0.9994965,0.00001616166,0.00007738714,0.0002330476,0.0001115641,0.00006533832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000384872,0.00005715481,0.008060596,0.00002775934,0.00001290659,1.631443e-7,0.00005091017,0.001046656,0.9879496,0.00002840191,0.00004238122,0.002684995],"study_design_scores_gemma":[0.0002750288,0.0002140006,0.02373412,0.000006401931,0.00001641121,2.395345e-7,0.00001266628,0.00012895,0.9596845,0.0001818317,0.01562659,0.0001192816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902606,0.0009818764,0.00525442,0.00004534495,0.0001001521,0.000274645,0.0000261745,0.000006222585,0.003050578],"genre_scores_gemma":[0.9937998,0.00005161587,0.004469354,0.00003298094,0.00009061228,0.000009013204,0.0001597158,0.00001684297,0.001370041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0282651,"threshold_uncertainty_score":0.4020078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009878866743951227,"score_gpt":0.2418644371798283,"score_spread":0.231985570435877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}