{"id":"W2907997089","doi":"10.1182/blood-2018-99-110439","title":"Efficacy and Safety of Single-Agent Quizartinib (Q), a Potent and Selective FLT3 Inhibitor (FLT3i), in Patients (pts) with FLT3-Internal Tandem Duplication (FLT3-ITD)-Mutated Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) Enrolled in the Global, Phase 3, Randomized Controlled Quantum-R Trial","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Refractory (planetary science); Medicine; Pharmacology; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00133576,0.0008613852,0.001493468,0.0002696748,0.0002690117,0.0008531245,0.0005325754,0.0009566137,0.002757813],"category_scores_gemma":[0.001374162,0.0004123556,0.001433905,0.0003062752,0.000793776,0.0008218407,0.0003501879,0.001870017,0.0004845612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009825694,"about_ca_system_score_gemma":0.00114434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001103014,"about_ca_topic_score_gemma":0.002612233,"domain_scores_codex":[0.9995565,0.0001941114,0.00002815401,0.0001026131,0.00003188753,0.00008673858],"domain_scores_gemma":[0.9991713,0.0001637171,0.0002399473,0.00004892258,0.0000509742,0.0003252056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9492612,0.00893726,0.004009485,0.0003803575,0.000907417,0.0000550941,0.00006447877,0.001202145,0.006226784,0.00009161808,0.001514265,0.02734994],"study_design_scores_gemma":[0.665382,0.3122085,0.01684876,0.00003553607,0.001395233,0.00011362,0.0000327496,0.001298228,0.001434263,0.0002229293,0.0009925258,0.00003554342],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957715,0.001255695,0.0002528823,0.0002063784,0.00007426675,0.0006781089,0.000885512,0.00003705861,0.0008385527],"genre_scores_gemma":[0.9973215,0.0004363328,0.0002575583,0.0002766464,0.00006901244,0.0004779506,0.0006471548,0.000006658971,0.000507195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002757813,"threshold_uncertainty_score":0.009225845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136844868066464,"score_gpt":0.2813758932956084,"score_spread":0.2700074446149437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}