{"id":"W2907997089","doi":"10.1182/blood-2018-99-110439","title":"Efficacy and Safety of Single-Agent Quizartinib (Q), a Potent and Selective FLT3 Inhibitor (FLT3i), in Patients (pts) with FLT3-Internal Tandem Duplication (FLT3-ITD)-Mutated Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) Enrolled in the Global, Phase 3, Randomized Controlled Quantum-R Trial","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Refractory (planetary science); Medicine; Pharmacology; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002913565,0.000565961,0.002428947,0.0004145188,0.0001699369,0.00007795497,0.0002959717,0.0003285856,0.00003022522],"category_scores_gemma":[0.002322166,0.0003529535,0.0002398091,0.0009020561,0.0007618822,0.0002104068,0.0001466119,0.000747864,0.00001096041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001071053,"about_ca_system_score_gemma":0.0009190253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003460826,"about_ca_topic_score_gemma":0.0001308897,"domain_scores_codex":[0.9940304,0.001488112,0.001810026,0.0008680844,0.001092373,0.000711068],"domain_scores_gemma":[0.9962461,0.00139255,0.0008732982,0.0005654069,0.000625,0.000297653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9708031,0.006041834,0.007963897,0.00005012354,0.00139595,0.0001080927,0.002194195,0.000004683724,0.009489479,0.00005960022,0.000130794,0.001758233],"study_design_scores_gemma":[0.9662567,0.01046734,0.01470931,0.0004238326,0.001357122,0.00009605301,0.0002798375,0.001573536,0.004369274,0.00006452893,0.00006796745,0.0003344916],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865729,0.0004125722,0.0001999272,0.0004675707,0.0001301112,0.01166075,0.00004943603,0.00005698459,0.0004497205],"genre_scores_gemma":[0.9983215,0.0002694901,0.000219747,0.0001696946,0.0002620392,0.000553552,0.00009854072,0.00005555271,0.00004990292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01174856,"threshold_uncertainty_score":0.9998922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136844868066464,"score_gpt":0.2813758932956084,"score_spread":0.2700074446149437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}