{"id":"W2908079023","doi":"10.1016/j.tips.2018.12.003","title":"Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome","year":2018,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Université de Montréal","keywords":"MDA5; RIG-I; Vaccine adjuvant; Computational biology; RNA; Adverse effect; Virology; Medicine; Biology; Pharmacology; Immunology; RNA interference; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001562632,0.000312859,0.0009830695,0.0003459802,0.0002716138,0.0000294567,0.001018364,0.0002953504,0.002751587],"category_scores_gemma":[0.000103252,0.0001445912,0.0002115912,0.0008274497,0.001732503,0.00005648217,0.0003454287,0.0004960042,0.0002352709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003977557,"about_ca_system_score_gemma":0.00006879143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003728286,"about_ca_topic_score_gemma":0.00002016415,"domain_scores_codex":[0.9971373,0.001149212,0.0006048043,0.0005137917,0.00007628297,0.0005186073],"domain_scores_gemma":[0.9986796,0.0008944885,0.0002355123,0.0001386357,0.00002551395,0.000026247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001104687,0.0001108562,0.00001437983,0.0001567459,0.0001321481,0.000004053906,0.00030102,4.561399e-7,0.004867431,0.0002166896,0.005845159,0.9882406],"study_design_scores_gemma":[0.0002174399,0.0007415562,0.0001574418,0.0004576841,0.0001706299,0.00003671895,0.00007083175,0.000002192796,0.002511703,0.0000223022,0.9953913,0.0002201678],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004958048,0.9917315,0.000001990908,0.0005216452,0.0009404712,0.0002607202,0.00003084761,0.00002472216,0.001530094],"genre_scores_gemma":[0.03950676,0.9560354,0.00004515193,0.0005798969,0.00007099282,0.00007050594,0.00001250461,0.000009704127,0.003669088],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9895462,"threshold_uncertainty_score":0.99816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1363498762434404,"score_gpt":0.4226989837684221,"score_spread":0.2863491075249817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}