{"id":"W2908079993","doi":"10.1161/atvbaha.118.312233","title":"Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells","year":2019,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Calcification; Biology; Ubiquitin ligase; Immunostaining; Downregulation and upregulation; Hypoxia (environmental); Cell biology; Population; Mesenchymal stem cell; Chemistry; Pathology; Immunology; Ubiquitin; Medicine; Biochemistry; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002284786,0.0003550412,0.0003150807,0.0001811992,0.0002411587,0.0003344411,0.0001624115,0.0003640207,0.001386818],"category_scores_gemma":[0.0001577454,0.0001631203,0.0003775942,0.0001245203,0.0004348159,0.0002196692,0.000186169,0.0004915991,0.0002402941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004040214,"about_ca_system_score_gemma":0.0002078801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005134059,"about_ca_topic_score_gemma":0.000519727,"domain_scores_codex":[0.9997857,0.00002547102,0.00002128902,0.00006906278,0.00004561942,0.00005281237],"domain_scores_gemma":[0.9999136,0.00001360889,0.00003280683,0.00001002799,0.000008273836,0.00002175483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004471668,0.00006872632,0.0002841556,0.00005457025,0.00001380802,0.00004884127,0.00001602971,0.00007132353,0.9978721,0.00009566997,0.00006604714,0.0009614973],"study_design_scores_gemma":[0.00003554306,0.0002965009,0.00287863,0.000003258765,0.00002121519,0.0001369959,0.00001586036,0.001112347,0.9941993,0.00004313658,0.001252795,0.000004408289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938815,0.001408588,0.003142204,0.0001158613,0.00006712948,0.00003025993,0.0003492387,0.0001312477,0.0008739114],"genre_scores_gemma":[0.9969648,0.0003235255,0.001261602,0.00007491363,0.000008917827,0.0000446333,0.0002525655,0.00001491155,0.001054221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001386818,"threshold_uncertainty_score":0.004639387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01884929474189289,"score_gpt":0.2832005315506753,"score_spread":0.2643512368087824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}