{"id":"W2908094279","doi":"10.1182/blood-2018-184","title":"MURANO Trial Establishes Feasibility of Time-Limited Venetoclax-Rituximab (VenR) Combination Therapy in Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Jewish General Hospital","funders":"","keywords":"Venetoclax; Medicine; Bendamustine; Rituximab; Internal medicine; Ven; Gastroenterology; Neutropenia; Minimal residual disease; Refractory (planetary science); Chronic lymphocytic leukemia; Oncology; Leukemia; Chemotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002975238,0.0004128255,0.001475387,0.0001800629,0.0001667989,0.0006641244,0.0005751725,0.0007504652,0.003735841],"category_scores_gemma":[0.001842147,0.0002268278,0.0008442663,0.0001639295,0.00056712,0.0005568898,0.0004158216,0.001521314,0.0004824028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006240883,"about_ca_system_score_gemma":0.0004970474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005005396,"about_ca_topic_score_gemma":0.001438514,"domain_scores_codex":[0.9983531,0.001272482,0.00004944044,0.0001495587,0.00006584176,0.0001096582],"domain_scores_gemma":[0.998635,0.0005037193,0.0003626734,0.0001496098,0.0000412547,0.0003076751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9248046,0.003119629,0.00563785,0.0004518992,0.0007168689,0.0001100839,0.00009118656,0.0007333964,0.007974936,0.0002910616,0.001346624,0.05472204],"study_design_scores_gemma":[0.5433339,0.4119288,0.03317844,0.0001904505,0.001462155,0.0003479783,0.00007881943,0.001503116,0.00163778,0.0006147278,0.005687678,0.00003614396],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911473,0.004348313,0.0002053707,0.0004228158,0.0001298028,0.0005671871,0.000376839,0.00004350797,0.002758736],"genre_scores_gemma":[0.9956776,0.0008220844,0.0005292142,0.0003440849,0.0001676781,0.0005328458,0.0005117189,0.000007770864,0.001406907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003735841,"threshold_uncertainty_score":0.01573479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03220331108193749,"score_gpt":0.306262982912542,"score_spread":0.2740596718306045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}