{"id":"W2908201785","doi":"10.1182/blood-2018-99-115123","title":"Age Subgroup Analysis of Health-Related Quality of Life of Blinatumomab Versus Standard-of-Care Chemotherapy in Patients with Relapsed or Refractory Philadelphia Chromosome-Negative B-Cell Precursor Acute Lymphoblastic Leukemia in a Randomized, Open-Label, Phase 3 Study (TOWER)","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Blinatumomab; Medicine; Internal medicine; Minimal residual disease; Chemotherapy; Gastroenterology; Oncology; Leukemia; Immunology; Surgery; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001905058,0.0008043166,0.002140729,0.0003189338,0.0002712707,0.0007340379,0.0004663588,0.0009291733,0.003010642],"category_scores_gemma":[0.001597922,0.0003058285,0.003844983,0.0003407818,0.0003384878,0.0006482759,0.0004579498,0.001556741,0.0002498559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005793049,"about_ca_system_score_gemma":0.0005670754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004632295,"about_ca_topic_score_gemma":0.001397051,"domain_scores_codex":[0.9990954,0.0004763972,0.000082769,0.0001576749,0.00009160767,0.0000961266],"domain_scores_gemma":[0.9990103,0.0002625403,0.0003086535,0.0001024124,0.00007885024,0.0002372039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9537367,0.003159682,0.01544798,0.0005592867,0.008227848,0.00005649414,0.00006753047,0.0004107742,0.0028247,0.00008531589,0.000849505,0.01457417],"study_design_scores_gemma":[0.5435982,0.2565306,0.1721234,0.000168476,0.0193634,0.0001827191,0.0002012312,0.002539002,0.00186917,0.000611492,0.002720863,0.00009145341],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940065,0.003772835,0.0002174659,0.0002307685,0.0001438471,0.0004241937,0.0007332265,0.00001702836,0.0004541079],"genre_scores_gemma":[0.9969959,0.0005432094,0.0003005875,0.0003401793,0.0001024141,0.0006322793,0.0007108561,0.000005286918,0.0003692999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003010642,"threshold_uncertainty_score":0.01007503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04176677496032077,"score_gpt":0.3666244567173212,"score_spread":0.3248576817570005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}