{"id":"W2908218354","doi":"10.1097/mph.0000000000001395","title":"Long-term Efficacy of Single-agent Vemurafenib for Pleomorphic Xanthoastrocytoma","year":2019,"lang":"en","type":"article","venue":"Journal of Pediatric Hematology/Oncology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"","keywords":"Vemurafenib; Pleomorphic xanthoastrocytoma; Medicine; Chemotherapy; Internal medicine; Oncology; V600E; Cancer research; Melanoma; Glioma; Mutation; Astrocytoma; Metastatic melanoma; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000275702,0.0002340876,0.0009792108,0.0001366925,0.0002120946,0.0002897669,0.0002212708,0.0003453687,0.0008027981],"category_scores_gemma":[0.0005327932,0.00006926251,0.0004165831,0.0001245626,0.0001210798,0.0003270407,0.0001624065,0.001119712,0.0003139895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002200385,"about_ca_system_score_gemma":0.0001837989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000189267,"about_ca_topic_score_gemma":0.0004299796,"domain_scores_codex":[0.9998974,0.00002023085,0.00001540527,0.0000155794,0.00001789267,0.00003359716],"domain_scores_gemma":[0.9996538,0.00007405946,0.00006729642,0.00002542296,0.00002834832,0.0001509746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.07734153,0.01848186,0.04618986,0.001499989,0.001919503,0.02488619,0.0007620571,0.005125496,0.1783873,0.0003719573,0.004752888,0.6402815],"study_design_scores_gemma":[0.01611015,0.4336066,0.3617373,0.0003026272,0.002190695,0.05916684,0.0005555925,0.007532218,0.08195382,0.000664251,0.0360058,0.0001741505],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919506,0.006711249,0.0002740232,0.0002055114,0.00006673118,0.00003310254,0.0001195365,0.00002910014,0.0006101361],"genre_scores_gemma":[0.9980179,0.0009819132,0.0000976,0.00008741877,0.00003517815,0.00002204077,0.0002450942,0.00000469165,0.0005081618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009792108,"threshold_uncertainty_score":0.002685606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02801861643328522,"score_gpt":0.2992152505258617,"score_spread":0.2711966340925764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}