{"id":"W2908303625","doi":"10.1073/pnas.1813161116","title":"Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric K <sub>v</sub> 1 channels","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Government of Canada","keywords":"Homomeric; Ion channel; Protein subunit; Biophysics; Chemistry; Potassium channel; Conotoxin; Heterologous expression; Biology; Population; Biochemistry; Cell biology; Peptide; Recombinant DNA; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001306033,0.0001272897,0.0001645895,0.0001455465,0.0002264111,0.00002306278,0.0007741367,0.0001174852,0.000006357297],"category_scores_gemma":[0.001325072,0.00009246394,0.0001046228,0.0009255132,0.0008793055,0.00002834726,0.0003432719,0.0001202404,0.00000550436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000187819,"about_ca_system_score_gemma":0.00004285546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001878001,"about_ca_topic_score_gemma":3.467113e-8,"domain_scores_codex":[0.9983521,0.0000111271,0.0003658048,0.000356414,0.0006813927,0.0002331719],"domain_scores_gemma":[0.999041,0.00003791005,0.0004670941,0.00001384154,0.0004029376,0.00003717327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001445579,0.00004378195,0.003345,0.00001644056,0.00002189256,4.674667e-10,0.00004666316,0.000009590137,0.9925829,0.0006555941,0.002511741,0.000751899],"study_design_scores_gemma":[0.0002124271,0.000192157,0.003277763,0.00002380099,0.000008418738,0.000005086896,0.00008823026,0.0001747215,0.9940556,0.0007920111,0.001058809,0.0001109944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963578,0.0001871251,0.00000723721,0.0005757398,0.00007067678,0.000218305,0.000009441455,0.000007514087,0.002566147],"genre_scores_gemma":[0.9981245,0.00006409673,0.0008901613,0.0003343134,0.000500218,0.00001558227,5.484183e-7,0.000007977548,0.00006259129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002503556,"threshold_uncertainty_score":0.377057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191006195481457,"score_gpt":0.2904942879841118,"score_spread":0.2685842260292972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}