{"id":"W2908303625","doi":"10.1073/pnas.1813161116","title":"Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric K <sub>v</sub> 1 channels","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Government of Canada","keywords":"Homomeric; Ion channel; Protein subunit; Biophysics; Chemistry; Potassium channel; Conotoxin; Heterologous expression; Biology; Population; Biochemistry; Cell biology; Peptide; Recombinant DNA; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002588547,0.0002336644,0.0002048896,0.0002518799,0.0001339326,0.0002913034,0.000269062,0.0003270903,0.0009052701],"category_scores_gemma":[0.0001663635,0.0001035557,0.0001716053,0.000115087,0.0001835061,0.0002812146,0.0001846298,0.0006402386,0.0003027866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002082668,"about_ca_system_score_gemma":0.0001558497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000190155,"about_ca_topic_score_gemma":0.0004294962,"domain_scores_codex":[0.9998311,0.00003131231,0.00001643619,0.00004033469,0.00004788246,0.00003290872],"domain_scores_gemma":[0.9999074,0.00001860533,0.0000310318,0.00001477735,0.000008357881,0.0000199212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004185072,0.00001991517,0.00006222379,0.00001951495,0.000002989611,0.00002795519,0.000004846019,0.00004258813,0.9982253,0.00009064843,0.00002248219,0.00143959],"study_design_scores_gemma":[0.00002094464,0.0003487895,0.001097576,0.000007406773,0.00001573537,0.0004157816,0.0000159393,0.000679865,0.9951087,0.00006445585,0.002221499,0.000003175894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612475,0.00548991,0.02735626,0.0003054127,0.0001025235,0.0001603801,0.0003173682,0.0002690938,0.004751482],"genre_scores_gemma":[0.9704321,0.002142595,0.02368471,0.0001420125,0.00001884579,0.00007632874,0.0003019707,0.00004344205,0.003157903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009052701,"threshold_uncertainty_score":0.003028452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191006195481457,"score_gpt":0.2904942879841118,"score_spread":0.2685842260292972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}