{"id":"W2908312420","doi":"10.1182/blood-2018-99-117198","title":"Postnatally Acquired Mutations Underlie the Progression of Transient Leukemia to Myeloid Leukemia of Down Syndrome","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; SickKids Foundation; Hospital for Sick Children; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"GATA1; Biology; Haploinsufficiency; Leukemia; Myeloid leukemia; Genetics; Mutation; Cancer research; Haematopoiesis; Gene; Phenotype; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009465522,0.0002212233,0.000129921,0.0001887649,0.00008944132,0.0001675869,0.000152756,0.0002414841,0.002105462],"category_scores_gemma":[0.0002475659,0.0001046689,0.0001232174,0.00008168866,0.0001627965,0.0001122089,0.0002236858,0.0002719349,0.000275391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409971,"about_ca_system_score_gemma":0.0001366681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006133866,"about_ca_topic_score_gemma":0.0005542072,"domain_scores_codex":[0.9999186,0.00001134967,0.00001031812,0.00002134935,0.0000210746,0.00001723408],"domain_scores_gemma":[0.9998556,0.0000432879,0.00004507015,0.000008104102,0.00001299262,0.00003494396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003173253,0.00003173681,0.01967242,0.00005718769,0.000008277525,0.002214618,0.00006447777,0.00006948264,0.974112,0.0002762436,0.0000532587,0.003123038],"study_design_scores_gemma":[0.0000556439,0.0008678004,0.355786,0.00003178602,0.0000758032,0.01903108,0.0002123727,0.001410581,0.617553,0.0002257414,0.0047344,0.00001584758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984331,0.0002415651,0.0006573106,0.00001456621,0.000005377475,0.000009009785,0.0002549043,0.00001951395,0.0003646587],"genre_scores_gemma":[0.9986705,0.0002051903,0.0003497282,0.00001295734,0.000002593703,0.000008737725,0.0002243407,0.000006789027,0.0005192004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002105462,"threshold_uncertainty_score":0.00704354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01833598061590127,"score_gpt":0.3022842175415736,"score_spread":0.2839482369256724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}