{"id":"W2908444719","doi":"10.1111/trf.15121","title":"Leukoreduction system chambers are a reliable cellular source for the manufacturing of T‐cell therapeutics","year":2018,"lang":"en","type":"article","venue":"Transfusion","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal; Héma-Québec; Hôpital Maisonneuve-Rosemont","funders":"Canadian Donation and Transplantation Research Program","keywords":"Leukoreduction; Peripheral blood mononuclear cell; Leukapheresis; Immunology; T cell; Medicine; Immune system; Cytotoxic T cell; Transplantation; Immunotherapy; Biology; CD34; Blood transfusion; Stem cell; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004039535,0.0001294691,0.0002223704,0.00006496772,0.0002501945,0.00001647601,0.0001124241,0.0001067835,0.0002994408],"category_scores_gemma":[0.000003173738,0.00008684134,0.0001564067,0.0001248158,0.0001703071,0.0000348133,0.00001279706,0.0001717083,0.00001402259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001024894,"about_ca_system_score_gemma":0.00005536692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002694932,"about_ca_topic_score_gemma":0.00002350603,"domain_scores_codex":[0.9989113,0.00003339374,0.0002262563,0.0002230711,0.0003470086,0.0002589878],"domain_scores_gemma":[0.9992406,0.00008930272,0.00007222166,0.0004127769,0.0001265647,0.00005852822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001318361,0.00008164255,0.0001721182,0.000644009,0.00007121683,0.000001898707,0.002446547,0.00006082208,0.9823726,0.00001361585,0.0001434412,0.01267367],"study_design_scores_gemma":[0.001605973,0.0005227957,0.0002842052,0.0001852973,0.0001559726,0.00002050314,0.002860777,0.005773062,0.9433843,0.000008737158,0.04511473,0.00008362457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789019,0.0004315791,0.01634976,0.0005603954,0.0003276331,0.001351599,0.000004778295,0.00007556981,0.001996817],"genre_scores_gemma":[0.9917614,0.0003057381,0.0004040303,0.00006683954,0.0003853251,0.00004036921,0.000006552702,0.00004693593,0.006982843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04497129,"threshold_uncertainty_score":0.3541287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03251321626058433,"score_gpt":0.278101575134179,"score_spread":0.2455883588735947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}