{"id":"W2908444719","doi":"10.1111/trf.15121","title":"Leukoreduction system chambers are a reliable cellular source for the manufacturing of T‐cell therapeutics","year":2018,"lang":"en","type":"article","venue":"Transfusion","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal; Héma-Québec; Hôpital Maisonneuve-Rosemont","funders":"Canadian Donation and Transplantation Research Program","keywords":"Leukoreduction; Peripheral blood mononuclear cell; Leukapheresis; Immunology; T cell; Medicine; Immune system; Cytotoxic T cell; Transplantation; Immunotherapy; Biology; CD34; Blood transfusion; Stem cell; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007425387,0.0006396591,0.0003140102,0.0003322943,0.0002700754,0.000792416,0.0004443963,0.0004852027,0.005192513],"category_scores_gemma":[0.0007155372,0.0002158782,0.0003933758,0.0002062545,0.0002555543,0.0003599241,0.0003501245,0.000448014,0.002467614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000258975,"about_ca_system_score_gemma":0.0003312695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001774104,"about_ca_topic_score_gemma":0.0002622811,"domain_scores_codex":[0.9989932,0.0002188583,0.0000873577,0.0001693641,0.0004678443,0.0000632719],"domain_scores_gemma":[0.9992415,0.0001767699,0.0002831919,0.0001369834,0.0001141407,0.00004759071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007361876,0.0000226072,0.0003507679,0.0001706827,0.00001089277,0.00008207583,0.00003592469,0.0002287151,0.9915563,0.0002508779,0.000320106,0.006897357],"study_design_scores_gemma":[0.00001991952,0.0003296753,0.001967885,0.00003026908,0.00003141956,0.0004578586,0.00002313382,0.0005459144,0.9764367,0.00008173634,0.02006467,0.00001079786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7008603,0.02002634,0.2463661,0.0007009942,0.0006261658,0.0008935741,0.004821039,0.002891358,0.02281409],"genre_scores_gemma":[0.9106424,0.004182146,0.07256136,0.0001874058,0.0001561054,0.0006332344,0.003816304,0.0003596625,0.007461272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005192513,"threshold_uncertainty_score":0.0173707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03251321626058433,"score_gpt":0.278101575134179,"score_spread":0.2455883588735947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}