{"id":"W2908458305","doi":"10.1111/cts.12604","title":"<scp>PF</scp>‐04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo‐Controlled Study","year":2018,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Pfizer","keywords":"Placebo; Randomized controlled trial; Medicine; Phosphodiesterase; Disease; Internal medicine; Sickle cell anemia; Randomization; Pharmacology; Bioinformatics; Biology; Biochemistry; Pathology; Enzyme; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001465852,0.001009731,0.001940827,0.0004589203,0.000338371,0.0006099804,0.0005718878,0.001392368,0.003230026],"category_scores_gemma":[0.0008962149,0.0004403652,0.001049117,0.000443071,0.0008182002,0.0005635773,0.0002291234,0.001695584,0.0005191616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004166245,"about_ca_system_score_gemma":0.001029027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005696652,"about_ca_topic_score_gemma":0.001342274,"domain_scores_codex":[0.9995479,0.0002339783,0.00003830918,0.00005916569,0.00004634766,0.00007421741],"domain_scores_gemma":[0.9992586,0.0001662233,0.00016731,0.00004350757,0.00005128405,0.0003129959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9143682,0.02141142,0.001528183,0.0006105764,0.000929598,0.00008770092,0.00006124707,0.0004700949,0.0195094,0.0001344638,0.0009784664,0.03991086],"study_design_scores_gemma":[0.7888888,0.2059095,0.002732456,0.00001832206,0.0002824849,0.00004965205,0.00001346559,0.0003169512,0.001234659,0.0000780086,0.0004649359,0.00001080887],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927047,0.002810037,0.0004559865,0.0003343993,0.0001497129,0.002090688,0.0004632848,0.00007730513,0.000913986],"genre_scores_gemma":[0.9910769,0.002295501,0.001311093,0.0008364472,0.000330175,0.002200948,0.0007088555,0.00001519691,0.001224821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003230026,"threshold_uncertainty_score":0.01080555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01614920063969432,"score_gpt":0.323549651346763,"score_spread":0.3074004507070687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}