{"id":"W2908458305","doi":"10.1111/cts.12604","title":"<scp>PF</scp>‐04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo‐Controlled Study","year":2018,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Pfizer","keywords":"Placebo; Randomized controlled trial; Medicine; Phosphodiesterase; Disease; Internal medicine; Sickle cell anemia; Randomization; Pharmacology; Bioinformatics; Biology; Biochemistry; Pathology; Enzyme; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002625975,0.0002126586,0.0007692238,0.0001500553,0.0003103125,0.00006510418,0.0001399647,0.00009477323,0.00007255231],"category_scores_gemma":[0.001811722,0.0001435814,0.0001974435,0.0005800975,0.002133101,0.0002882503,0.00004511008,0.0003106538,0.00003508913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001548002,"about_ca_system_score_gemma":0.0005271205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004600928,"about_ca_topic_score_gemma":0.00003110752,"domain_scores_codex":[0.9970844,0.0002197942,0.0009818538,0.0006365146,0.0006569625,0.000420462],"domain_scores_gemma":[0.9973983,0.001375943,0.0001434857,0.00021166,0.0002674764,0.0006031944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2288042,0.02417878,0.7278214,0.0001061823,0.0001436831,0.0001147582,0.005044292,0.00005469868,0.00009657763,0.0004892128,0.0007193948,0.01242685],"study_design_scores_gemma":[0.9075197,0.001590841,0.07611938,0.000130759,0.000329175,0.00000182271,0.0006460923,0.0107278,0.00004964092,0.001227134,0.001501878,0.0001557581],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924668,0.0007297092,0.000170684,0.000560548,0.0003573277,0.002535991,0.00002340999,0.0000324972,0.003123045],"genre_scores_gemma":[0.9982827,0.0001438976,0.0002249195,0.0005863993,0.0001311127,0.00008800763,0.00001519183,0.0000112713,0.0005164928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6787155,"threshold_uncertainty_score":0.7859498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01614920063969432,"score_gpt":0.323549651346763,"score_spread":0.3074004507070687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}