{"id":"W2908467301","doi":"10.1021/acscentsci.8b00773","title":"A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury","year":2019,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"American Heart Association; National Center for Research Resources; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Division of Chemistry; Division of Graduate Education","keywords":"Uniporter; Bioenergetics; Mitochondrion; Cell biology; Cytosol; Biology; Calcium; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358076,0.0002947643,0.0003105809,0.000194036,0.000186238,0.0002764759,0.0004100445,0.0003437279,0.001174646],"category_scores_gemma":[0.0001614896,0.00009403571,0.0001754087,0.0001283851,0.0002233361,0.0001842926,0.0001500534,0.0004319806,0.0003365919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002501186,"about_ca_system_score_gemma":0.0002648373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007234904,"about_ca_topic_score_gemma":0.00104561,"domain_scores_codex":[0.9998944,0.00001703298,0.000008641327,0.00003035158,0.00002515708,0.0000245101],"domain_scores_gemma":[0.9999278,0.00001706262,0.00002188633,0.000009109788,0.000007094136,0.00001696386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002049723,0.00003099116,0.00005824136,0.0000452928,0.000006461457,0.00004648719,0.00001184655,0.00006224833,0.9968958,0.00017109,0.00006712906,0.002399449],"study_design_scores_gemma":[0.00001618872,0.0002896422,0.0004703141,0.000002787176,0.00001035981,0.0001944152,0.00000500843,0.0003245887,0.9974054,0.00001471919,0.001264116,0.000002546987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842609,0.005244962,0.007270826,0.0001421239,0.00004779988,0.00004606889,0.0004284572,0.0003675266,0.002191389],"genre_scores_gemma":[0.9936424,0.001179944,0.003056672,0.00003149516,0.00001754441,0.00002331639,0.0003778976,0.00002651769,0.001644087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174646,"threshold_uncertainty_score":0.003929615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006804705284149825,"score_gpt":0.2279256045098622,"score_spread":0.2211208992257123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}