{"id":"W2908470212","doi":"10.1101/gad.320069.118","title":"ZNF445 is a primary regulator of genomic imprinting","year":2019,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Medical Research Council; Medical Research Council Canada; European Commission; Wellcome Trust; Gebert Rüf Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Genomic imprinting; Imprinting (psychology); Reprogramming; Epigenetics; DNA methylation; Penetrance; Genetics; Regulator; Regulation of gene expression; Zinc finger; Gene; Phenotype; Gene expression; Cell biology; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001936711,0.0001537203,0.0001888215,0.00004391127,0.00004309413,0.00001238143,0.0002143825,0.00009598674,0.0001360417],"category_scores_gemma":[0.000006376206,0.0001526601,0.00007888006,0.00005363462,0.00002242764,0.000001939989,0.0003654116,0.00004009601,0.0001125379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002428807,"about_ca_system_score_gemma":0.0002158557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006877337,"about_ca_topic_score_gemma":0.000001427111,"domain_scores_codex":[0.9988517,0.00001582425,0.0003471181,0.0003594136,0.0001480201,0.0002779301],"domain_scores_gemma":[0.9993558,0.000004239822,0.0001387941,0.0003732843,0.00006899908,0.00005888063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004865225,0.00001803567,0.0569596,0.00006362505,0.00006200391,2.357353e-7,0.0001552628,0.00001923148,0.8865772,0.000009337624,0.000123253,0.05600737],"study_design_scores_gemma":[0.0002685626,0.00004487702,0.3399546,0.00001690558,0.000005972413,0.00001476699,0.00006297066,0.0000114121,0.5814118,0.000008817078,0.078032,0.0001673586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961339,0.001264265,0.0003151794,0.00003401187,0.0002173213,0.0002043574,0.000002012606,0.000008438575,0.001820528],"genre_scores_gemma":[0.9767793,0.0001355104,0.02090155,0.0002368461,0.00006445347,0.00001214712,0.00002683198,0.00002677795,0.001816572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3051654,"threshold_uncertainty_score":0.6225299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005898302427109366,"score_gpt":0.2027504699422515,"score_spread":0.1968521675151422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}