{"id":"W2908525626","doi":"10.1002/cpt.1375","title":"Drug‐Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles","year":2019,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"NIHR Nottingham Biomedical Research Centre; European Regional Development Fund; Medical Research Council; Svenska Läkaresällskapet; Uppsala Universitet; Radboud Universitair Medisch Centrum; Karolinska Institutet; University of Nottingham; King's College London; Daiichi-Sankyo; Abbott Laboratories; National Institute for Health and Care Research; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Nottingham University Hospitals NHS Trust; King’s College London; Roche; Instituto de Salud Carlos III; Amgen; Radboud Universiteit; Newcastle University; Novartis; AstraZeneca; Vetenskapsrådet; University of Warwick; Pfizer; Merck; Directorate for Biological Sciences; GlaxoSmithKline; Sanofi; Wellcome; Universiteit Utrecht","keywords":"Flucloxacillin; Human leukocyte antigen; Odds ratio; Allele; Medicine; Immunology; Penicillin; HLA-B; Genotype; Internal medicine; Biology; Antigen; Antibiotics; Gene; Genetics; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002646906,0.0005735497,0.001187703,0.0002659528,0.0004219088,0.00002098888,0.0009696392,0.001226782,0.002290525],"category_scores_gemma":[0.00009402115,0.000584979,0.0004887909,0.0005295268,0.0005147983,0.0002117003,0.0003390723,0.002826796,0.00173476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001562195,"about_ca_system_score_gemma":0.0002474796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005786054,"about_ca_topic_score_gemma":0.0000651764,"domain_scores_codex":[0.9937172,0.00229359,0.001677545,0.0009954215,0.0003402876,0.0009759822],"domain_scores_gemma":[0.9953473,0.002488605,0.0006464348,0.0005999317,0.0003970376,0.0005207397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002728923,0.00175141,0.03525618,0.0001442407,0.001276325,0.00006388099,0.00115378,0.000438533,0.9082081,0.0001164588,0.009260171,0.03960204],"study_design_scores_gemma":[0.004280949,0.001188193,0.01238786,0.00003809314,0.0004576659,0.00001726955,0.0001112221,0.003045462,0.6008505,0.0002740267,0.3766542,0.0006945572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855313,0.000481632,0.0001208716,0.002453628,0.007758039,0.002236779,0.00008668721,0.0002368648,0.001094244],"genre_scores_gemma":[0.953761,0.001608631,0.0004098999,0.04180075,0.001121862,0.0001198528,0.00002869869,0.00009202804,0.001057263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.367394,"threshold_uncertainty_score":0.9996601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2222302714129458,"score_gpt":0.4858570597651821,"score_spread":0.2636267883522364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}