{"id":"W2908525626","doi":"10.1002/cpt.1375","title":"Drug‐Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles","year":2019,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"NIHR Nottingham Biomedical Research Centre; European Regional Development Fund; Medical Research Council; Svenska Läkaresällskapet; Uppsala Universitet; Radboud Universitair Medisch Centrum; Karolinska Institutet; University of Nottingham; King's College London; Daiichi-Sankyo; Abbott Laboratories; National Institute for Health and Care Research; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Nottingham University Hospitals NHS Trust; King’s College London; Roche; Instituto de Salud Carlos III; Amgen; Radboud Universiteit; Newcastle University; Novartis; AstraZeneca; Vetenskapsrådet; University of Warwick; Pfizer; Merck; Directorate for Biological Sciences; GlaxoSmithKline; Sanofi; Wellcome; Universiteit Utrecht","keywords":"Flucloxacillin; Human leukocyte antigen; Odds ratio; Allele; Medicine; Immunology; Penicillin; HLA-B; Genotype; Internal medicine; Biology; Antigen; Antibiotics; Gene; Genetics; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006180981,0.0001955197,0.0003886107,0.0003946249,0.0001810281,0.0003846379,0.0001428197,0.0002373595,0.002308188],"category_scores_gemma":[0.002066199,0.000148645,0.0004058105,0.0005455987,0.000294409,0.0001878694,0.0002323578,0.0003429737,0.0001881041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000197834,"about_ca_system_score_gemma":0.0001749811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001738315,"about_ca_topic_score_gemma":0.002112532,"domain_scores_codex":[0.999495,0.0002054924,0.00005534821,0.00009256325,0.00009102604,0.00006052059],"domain_scores_gemma":[0.998717,0.0006076579,0.0003980822,0.0001243574,0.00006401431,0.00008888906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006216829,0.00005116958,0.9794266,0.0000361552,0.0001683113,0.00101025,0.00005985789,0.00009235637,0.006177716,0.00005324409,0.00006122014,0.01224144],"study_design_scores_gemma":[0.00001781449,0.0001848101,0.9953825,0.000007678917,0.00009309199,0.002255635,0.00004918847,0.0003251951,0.001397923,0.00005335667,0.0002297103,0.000003023942],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989089,0.0004336306,0.0002517366,0.00004592296,0.000002023017,0.000003660832,0.00003723224,0.000004325927,0.0003125803],"genre_scores_gemma":[0.9996163,0.0001013587,0.0001218406,0.00002766805,0.000004102238,0.0000014006,0.0000504119,0.00000180834,0.00007502088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002308188,"threshold_uncertainty_score":0.007721663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2222302714129458,"score_gpt":0.4858570597651821,"score_spread":0.2636267883522364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}