{"id":"W2908576524","doi":"10.3389/fmicb.2018.03351","title":"Discovery of a New Natural Product and a Deactivation of a Quorum Sensing System by Culturing a “Producer” Bacterium With a Heat-Killed “Inducer” Culture","year":2019,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"National Research Council Canada; Agriculture and Agri-Food Canada; Fondation Jean-Louis Lévesque; Natural Sciences and Engineering Research Council of Canada; Atlantic Canada Opportunities Agency; Innovation PEI","keywords":"Inducer; Quorum sensing; Natural product; Pseudomonas aeruginosa; Streptomyces; Bacteria; Fermentation; Microbiology; Biochemistry; Biology; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002229208,0.0002773601,0.0001855687,0.0001850595,0.0001257797,0.0002714888,0.000228035,0.0003505873,0.0006983152],"category_scores_gemma":[0.0001885006,0.0001278172,0.0003125863,0.0001282259,0.0002724688,0.0002984469,0.0002281812,0.0006237571,0.0002026259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199419,"about_ca_system_score_gemma":0.0002880951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002242166,"about_ca_topic_score_gemma":0.0004604986,"domain_scores_codex":[0.9999124,0.00001423771,0.000006737384,0.00002078055,0.00002637669,0.00001950866],"domain_scores_gemma":[0.9998994,0.00001773424,0.00001689803,0.00001323731,0.00002221075,0.00003059383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000520307,0.00005536347,0.00008950815,0.00004978326,0.000003684819,0.0001168348,0.00001615295,0.00007696939,0.9946229,0.0005488453,0.00008820478,0.004279703],"study_design_scores_gemma":[0.00003637269,0.0006256048,0.0008859237,0.000007914878,0.00001288846,0.0003813869,0.00002091836,0.0006011465,0.9906946,0.0002819872,0.006441647,0.000009532437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453137,0.005926485,0.04082805,0.001261364,0.0003112568,0.0002885267,0.0007163122,0.0002029259,0.005151407],"genre_scores_gemma":[0.9646425,0.002450814,0.02811226,0.0001967851,0.00003660849,0.00009424114,0.0005660187,0.00001950928,0.00388125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006983152,"threshold_uncertainty_score":0.002336144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0023565337520338,"score_gpt":0.1754124929994561,"score_spread":0.1730559592474223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}