{"id":"W2908652588","doi":"10.1002/art.40840","title":"A Phase <scp>II</scp> Trial of Lutikizumab, an Anti–Interleukin‐1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis","year":2019,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":211,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"AbbVie","keywords":"Synovitis; Osteoarthritis; Medicine; Antibody; Dual (grammatical number); Immunology; Arthritis; Pathology; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001008841,0.001081375,0.0009553154,0.000268024,0.0002734168,0.0005979141,0.0004377601,0.0008219555,0.0037743],"category_scores_gemma":[0.0005669133,0.0003002603,0.0007508314,0.0002361162,0.0004996574,0.0003559485,0.0001593494,0.001629354,0.0006403606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004441314,"about_ca_system_score_gemma":0.0007934387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000561131,"about_ca_topic_score_gemma":0.001621451,"domain_scores_codex":[0.9997929,0.0001088936,0.00001212456,0.00002572744,0.00002472589,0.0000356519],"domain_scores_gemma":[0.9996081,0.00007975439,0.0001047792,0.00001992658,0.00003030541,0.0001571929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8301562,0.01479975,0.004255282,0.001798818,0.001330713,0.0002181741,0.0001228296,0.0006894332,0.04271709,0.000195073,0.005280957,0.09843572],"study_design_scores_gemma":[0.871423,0.1158791,0.007867126,0.00005938214,0.0003748442,0.0002707438,0.00002137156,0.000525031,0.001887142,0.00008746783,0.001593517,0.00001129618],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883174,0.005674574,0.0004117598,0.0007788655,0.0002089101,0.001839936,0.0007405829,0.0001077264,0.001920228],"genre_scores_gemma":[0.9877918,0.003218254,0.001192757,0.001522856,0.0003820829,0.002125092,0.001516619,0.00001685603,0.002233569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0037743,"threshold_uncertainty_score":0.01262623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005385550226726681,"score_gpt":0.2413307508431664,"score_spread":0.2359452006164397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}