{"id":"W2908658437","doi":"10.3389/fnmol.2018.00480","title":"PKR: A Kinase to Remember","year":2019,"lang":"en","type":"review","venue":"Frontiers in Molecular Neuroscience","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":260,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Health, State of Israel; Ministry of Science and Technology, Israel; Azrieli Foundation; Israel Science Foundation; International Development Research Centre; Canadian Institutes of Health Research; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Protein kinase R; Neurodegeneration; Biology; Kinase; Cellular stress response; Cell biology; Protein kinase A; Regulator; Signal transduction; Function (biology); EIF-2 kinase; Neuroscience; Bioinformatics; Medicine; Genetics; Fight-or-flight response; Disease; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2; Gene; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001737851,0.0003721037,0.0006376869,0.0002967403,0.00004533031,0.00007013814,0.0007496407,0.0002413386,0.00000741572],"category_scores_gemma":[0.0002560266,0.0003560539,0.0002744675,0.0006296948,0.0001014817,0.000005347166,0.0003077115,0.0001733012,0.00005440226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000462479,"about_ca_system_score_gemma":0.0003592329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002743612,"about_ca_topic_score_gemma":0.000001097114,"domain_scores_codex":[0.9976324,0.0001822574,0.0003806181,0.001051443,0.0003167568,0.0004364877],"domain_scores_gemma":[0.9986151,0.000004449871,0.0001370997,0.0009450015,0.00003033612,0.0002679533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006522959,0.000258274,0.0003203858,0.00415993,0.00003233265,0.0004677869,0.00001846596,0.000820634,0.01512967,0.0001681833,0.09424111,0.884318],"study_design_scores_gemma":[0.0001470466,0.00007760973,0.00002581802,0.0004028253,0.00005665716,0.00001614723,0.000003065097,0.00005683406,0.0001406799,0.000009951524,0.9986671,0.0003962402],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001032055,0.9830303,0.01315361,0.00003327375,0.001747363,0.0009538514,0.00004690044,0.00001618506,0.0009153633],"genre_scores_gemma":[0.00008358514,0.9922556,0.002882335,0.001783378,0.00007779489,0.000102995,0.0001325054,0.0000778246,0.002603935],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.904426,"threshold_uncertainty_score":0.9998891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02456626216326045,"score_gpt":0.3117492811408021,"score_spread":0.2871830189775417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}