{"id":"W2908798408","doi":"10.1101/521393","title":"HDAC and MAPK/ERK Inhibitors Cooperate to Reduce Viability and Stemness in Medulloblastoma","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Cancer Society Research Institute; National Institutes of Health; Fundação Instituto de Pesquisas Econômicas; Terry Fox Research Institute; Hospital de Clínicas de Porto Alegre; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Brain Tumour Foundation of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Genome British Columbia; Ontario Institute for Cancer Research; American Brain Tumor Association; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Genome Canada","keywords":"MAPK/ERK pathway; Homeobox protein NANOG; BMI1; Cancer stem cell; Cancer research; Biology; Histone deacetylase; SOX2; Embryonic stem cell; Stem cell; RHOA; Neural stem cell; Neurosphere; Cell biology; Signal transduction; Histone; Genetics; Adult stem cell; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009372892,0.0003397052,0.0002546214,0.0002327902,0.0001064725,0.0001408308,0.0001805335,0.0001098551,0.001032033],"category_scores_gemma":[0.00006000237,0.00009737608,0.0002013571,0.0001064551,0.0001114472,0.00009467544,0.0001161221,0.0003214004,0.0001915637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000257443,"about_ca_system_score_gemma":0.0001743762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009662657,"about_ca_topic_score_gemma":0.002522788,"domain_scores_codex":[0.9999406,0.000009297561,0.000006112755,0.00001025944,0.0000168385,0.00001695727],"domain_scores_gemma":[0.9999769,0.000003931469,0.000005038468,0.000002682359,0.000002596635,0.000008850532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004929499,0.0001249845,0.0004644963,0.00005339204,0.00001612682,0.0000334526,0.000009460626,0.0001351748,0.994041,0.00007920054,0.0001095057,0.004440185],"study_design_scores_gemma":[0.00008995702,0.001026689,0.009148081,0.000005428109,0.00003974937,0.0002022833,0.00001882872,0.001337347,0.9849819,0.00004032204,0.003106221,0.000003195424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946116,0.002458829,0.0008797788,0.00007294408,0.0000321735,0.00003110361,0.000342513,0.00009753395,0.001473513],"genre_scores_gemma":[0.9953207,0.001220898,0.001053095,0.00002480487,0.000008800697,0.00003294908,0.0004784567,0.00001503179,0.00184529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001032033,"threshold_uncertainty_score":0.00345248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009572731179865509,"score_gpt":0.2445007747988785,"score_spread":0.234928043619013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}