{"id":"W2908879131","doi":"10.1101/518035","title":"Srs2 helicase prevents the formation of toxic DNA damage during late prophase I of yeast meiosis","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; York University","keywords":"RAD51; Homologous recombination; Chromosome segregation; Biology; Helicase; Prophase; DNA damage; DNA repair; Cell biology; Meiosis; G2-M DNA damage checkpoint; Genetic recombination; DNA; Molecular biology; Chromosome; Genetics; Gene; Recombination; Cell cycle checkpoint; Cell cycle","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090681,0.0004840154,0.0002845071,0.0001751647,0.0001251529,0.0003198534,0.0002359378,0.0002369206,0.001759901],"category_scores_gemma":[0.000108964,0.0001860178,0.000178498,0.00006593151,0.0001513977,0.0001300063,0.0002162577,0.0003458229,0.0006944296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159997,"about_ca_system_score_gemma":0.0001778828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000564065,"about_ca_topic_score_gemma":0.001021756,"domain_scores_codex":[0.9998832,0.00001658138,0.00001582008,0.00002278531,0.00003778825,0.00002376376],"domain_scores_gemma":[0.9998015,0.00002048519,0.00005163772,0.0000269639,0.00002238097,0.00007714894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004687622,0.000006954099,0.00008562287,0.00001620435,0.000002272874,0.00002914413,0.000005255451,0.00001490113,0.999479,0.00002020728,0.00002079686,0.0002728846],"study_design_scores_gemma":[0.000020081,0.0002724302,0.004532332,0.000006596255,0.000008273053,0.0002356141,0.00002710711,0.000440365,0.9913857,0.00002464184,0.003043026,0.000003921705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944088,0.001333722,0.002377245,0.00006648125,0.00003618913,0.0000278576,0.0004619457,0.0002002473,0.001087524],"genre_scores_gemma":[0.9927759,0.0003718323,0.000764111,0.00003954895,0.00001214725,0.00002732027,0.001227746,0.00005441233,0.004726901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759901,"threshold_uncertainty_score":0.005887389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008997076592173452,"score_gpt":0.2148482915433454,"score_spread":0.205851214951172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}