{"id":"W2908931882","doi":"10.1099/jgv.0.001217","title":"Beyond sites 1 and 2, miR-122 target sites in the HCV genome have negligible contributions to HCV RNA accumulation in cell culture","year":2019,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"NS5B; Biology; Internal ribosome entry site; RNA; Virology; Untranslated region; RNA-dependent RNA polymerase; Viral replication; Viral structural protein; Hepatitis C virus; Mutant; NS2-3 protease; Molecular biology; Virus; Gene; Genetics; Viral entry; Hepacivirus; Ribosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003453806,0.0001261546,0.0002063022,0.0001349706,0.00003890302,0.00002638993,0.0001703691,0.0001940083,0.00003459327],"category_scores_gemma":[0.00007500527,0.00009515868,0.00007101834,0.0001101384,0.00003454285,0.0000153755,0.0000638896,0.0001697559,0.000006682396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004214685,"about_ca_system_score_gemma":0.00005322808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001240811,"about_ca_topic_score_gemma":0.00007463903,"domain_scores_codex":[0.9989547,0.0001843058,0.0003541484,0.0001837304,0.0001076895,0.0002154978],"domain_scores_gemma":[0.9994273,0.00002496512,0.0001937071,0.0001646554,0.0001195038,0.00006982128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001666186,0.00009924145,0.03189541,0.000008135239,0.00001633337,0.000008163869,0.00022765,0.005505093,0.9604307,0.00008579947,0.001522406,0.00003443241],"study_design_scores_gemma":[0.007543954,0.002028943,0.6280049,0.0000245149,0.00008849498,0.0001336181,0.0003247217,0.002401289,0.2903501,0.004612258,0.06390832,0.0005789393],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956651,0.002305173,0.0002679729,0.001055138,0.00007338162,0.0002440819,0.00003983795,0.000001503764,0.0003478265],"genre_scores_gemma":[0.9973984,0.0001280416,0.0008586631,0.0009660257,0.0002895959,0.000005449849,0.0001352444,0.000009849599,0.0002086875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6700807,"threshold_uncertainty_score":0.3880458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008531542209790863,"score_gpt":0.2758155545795934,"score_spread":0.2672840123698026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}