{"id":"W2908931882","doi":"10.1099/jgv.0.001217","title":"Beyond sites 1 and 2, miR-122 target sites in the HCV genome have negligible contributions to HCV RNA accumulation in cell culture","year":2019,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"NS5B; Biology; Internal ribosome entry site; RNA; Virology; Untranslated region; RNA-dependent RNA polymerase; Viral replication; Viral structural protein; Hepatitis C virus; Mutant; NS2-3 protease; Molecular biology; Virus; Gene; Genetics; Viral entry; Hepacivirus; Ribosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001651683,0.0003890976,0.0005138279,0.0001456728,0.0002259539,0.0003877176,0.0002621678,0.0002514813,0.002022991],"category_scores_gemma":[0.0002080471,0.0002133793,0.0003193007,0.0001501914,0.0002049539,0.0001949614,0.0001986288,0.0005223224,0.0008783693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000323274,"about_ca_system_score_gemma":0.0004374234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001562234,"about_ca_topic_score_gemma":0.002202143,"domain_scores_codex":[0.9997501,0.00004542079,0.00003516646,0.00005788228,0.00008195204,0.00002940871],"domain_scores_gemma":[0.9997351,0.00008210218,0.00004783496,0.00004956112,0.00003993369,0.00004561023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007437632,0.00001827608,0.0001496316,0.00002989191,0.000002584413,0.00002147104,0.00001157696,0.00004468808,0.9989635,0.00005228862,0.00002386041,0.0006078042],"study_design_scores_gemma":[0.00000882219,0.0002982757,0.001728877,0.000005841174,0.00001215258,0.0001407702,0.00001369025,0.000627304,0.9941023,0.00003024101,0.003026077,0.000005559211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884859,0.002253654,0.005258823,0.00008401163,0.00007211586,0.00007741048,0.0007968673,0.0001322231,0.002838869],"genre_scores_gemma":[0.9750984,0.001811826,0.01165387,0.00009766991,0.00001922559,0.0001490857,0.002949448,0.00007110252,0.008149423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022991,"threshold_uncertainty_score":0.006767571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008531542209790863,"score_gpt":0.2758155545795934,"score_spread":0.2672840123698026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}