{"id":"W2909001246","doi":"10.1093/hmg/ddz018","title":"A study in scarlet: MC1R as the main predictor of red hair and exemplar of the flip-flop effect","year":2019,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University","funders":"National Institutes of Health; Canada Excellence Research Chairs, Government of Canada","keywords":"Biology; Melanocortin 1 receptor; Genetics; Haplotype; Single-nucleotide polymorphism; Loss function; Phenotype; Evolutionary biology; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003378157,0.0001304698,0.00016714,0.00003316658,0.00004040494,0.00001047305,0.0002560328,0.0000881847,0.00001329529],"category_scores_gemma":[0.00003620448,0.00008799564,0.00006848005,0.00009218316,0.0000944149,0.000001335283,0.0001757683,0.0000779477,0.000001444601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007616226,"about_ca_system_score_gemma":0.00003166735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002454914,"about_ca_topic_score_gemma":0.00005221997,"domain_scores_codex":[0.998839,0.0003098524,0.0002558669,0.0002375501,0.000220805,0.0001369793],"domain_scores_gemma":[0.9992422,0.00001712917,0.000117083,0.000560583,0.00003614076,0.00002686592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004223049,0.00006800016,0.1259662,0.00002812831,0.0000494872,0.000003392256,0.0003669106,0.0001174166,0.8730834,0.00006808226,0.00006778751,0.0001389694],"study_design_scores_gemma":[0.001606658,0.001371394,0.3883768,0.00003313777,0.00004914778,0.000009195784,0.0002978907,0.00004626795,0.6076809,0.000144507,0.0002684843,0.0001156175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976956,0.0006438944,0.00003197768,0.00002993157,0.00008352823,0.0009589113,0.000008231577,0.00000226171,0.0005457014],"genre_scores_gemma":[0.9996165,0.00003247481,0.00005461453,0.00007215817,0.00002423487,0.00002323608,0.0000157863,0.00001918322,0.0001418322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2654025,"threshold_uncertainty_score":0.3588358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006368534899360157,"score_gpt":0.2552709870498402,"score_spread":0.24890245215048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}