{"id":"W2909001246","doi":"10.1093/hmg/ddz018","title":"A study in scarlet: MC1R as the main predictor of red hair and exemplar of the flip-flop effect","year":2019,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University","funders":"National Institutes of Health; Canada Excellence Research Chairs, Government of Canada","keywords":"Biology; Melanocortin 1 receptor; Genetics; Haplotype; Single-nucleotide polymorphism; Loss function; Phenotype; Evolutionary biology; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002351601,0.0004181092,0.0003853964,0.000396321,0.0005675891,0.0005797382,0.0004360697,0.0007088657,0.003856499],"category_scores_gemma":[0.004590056,0.000185858,0.0008674902,0.0005731442,0.0004403289,0.0003163111,0.0005824741,0.0007934247,0.00031239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001749392,"about_ca_system_score_gemma":0.0002608076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004363662,"about_ca_topic_score_gemma":0.006150849,"domain_scores_codex":[0.9988328,0.0004530753,0.00006703466,0.0004162727,0.0001379447,0.00009288645],"domain_scores_gemma":[0.9968334,0.001340625,0.0006186725,0.0005832095,0.0001977096,0.0004263618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005150504,0.0001423857,0.9603878,0.0001893739,0.001410093,0.003025927,0.001537385,0.0001292335,0.009739117,0.0009828761,0.002770681,0.01453461],"study_design_scores_gemma":[0.0001714223,0.0008842211,0.9910854,0.00005982423,0.0008905547,0.002502505,0.0002946416,0.0006077334,0.000652622,0.0003680359,0.002466748,0.00001630217],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977849,0.0005216796,0.0005255723,0.0002184764,0.00005427676,0.00001108159,0.0002676564,0.000008165888,0.0006082522],"genre_scores_gemma":[0.9981141,0.0001049127,0.0004029961,0.0002288116,0.00005501426,0.00001023319,0.0002166983,0.00001166018,0.0008555928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004363662,"threshold_uncertainty_score":0.01290131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006368534899360157,"score_gpt":0.2552709870498402,"score_spread":0.24890245215048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}