{"id":"W2909011032","doi":"10.1128/jvi.02051-18","title":"Establishment of a Novel Humanized Mouse Model To Investigate <i>In Vivo</i> Activation and Depletion of Patient-Derived HIV Latent Reservoirs","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic","funders":"National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse","keywords":"Viremia; Humanized mouse; In vivo; Biology; Virology; Peripheral blood mononuclear cell; Population; Immunology; Human immunodeficiency virus (HIV); Antibody; In vitro; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001199867,0.001242685,0.0004626221,0.001070256,0.0003246497,0.0009726236,0.0008726715,0.0009549292,0.003328125],"category_scores_gemma":[0.0003389794,0.0004483504,0.0004545058,0.000240489,0.0006919621,0.0008380517,0.0004320341,0.002588496,0.0007291353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004794624,"about_ca_system_score_gemma":0.0005391655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005177129,"about_ca_topic_score_gemma":0.0006320688,"domain_scores_codex":[0.9995134,0.0001222163,0.00004923679,0.0001349642,0.00008608457,0.00009415248],"domain_scores_gemma":[0.9996238,0.00007754718,0.00008908872,0.00008305637,0.00003976398,0.00008670372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008044892,0.0009247229,0.0005298716,0.00007591681,0.00002675276,0.0002412965,0.00008086035,0.0003774584,0.9890841,0.00233777,0.0006974009,0.00481935],"study_design_scores_gemma":[0.0004862107,0.007240411,0.002284511,0.00008529272,0.0001354282,0.004256629,0.0000901364,0.004880329,0.9550493,0.0008628196,0.0245853,0.00004342198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8751069,0.004253474,0.1031113,0.001434203,0.000606224,0.001716687,0.003392913,0.001303638,0.00907466],"genre_scores_gemma":[0.9212467,0.003202016,0.05703992,0.0006572933,0.0001452174,0.001532704,0.003722549,0.0001762174,0.0122774],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.003328125,"threshold_uncertainty_score":0.01113367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02164850610480742,"score_gpt":0.2503412054439846,"score_spread":0.2286926993391772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}