{"id":"W2909035282","doi":"10.1155/2019/6403274","title":"Detection of Active Caspase-3 in Mouse Models of Stroke and Alzheimer’s Disease with a Novel Dual Positron Emission Tomography/Fluorescent Tracer [<sup>68</sup>Ga]Ga-TC3-OGDOTA","year":2019,"lang":"en","type":"article","venue":"Contrast Media & Molecular Imaging","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alzheimer's Society; Sanofi","keywords":"In vivo; Colocalization; Apoptosis; In vitro; Positron emission tomography; Chemistry; Neuroscience; Cell biology; Pathology; Medicine; Cancer research; Biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001327104,0.0002751596,0.000327181,0.0001690222,0.00003649562,0.00002030185,0.000124853,0.0000938898,0.000007420675],"category_scores_gemma":[0.00004014315,0.0002498424,0.0001270738,0.0001338456,0.0001456745,0.00002977616,0.0000886323,0.0001740526,4.316997e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001754485,"about_ca_system_score_gemma":0.0001086643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001614986,"about_ca_topic_score_gemma":0.00003116922,"domain_scores_codex":[0.9984871,0.00007029086,0.0003171772,0.000508861,0.0002745636,0.0003419657],"domain_scores_gemma":[0.9990886,0.00001990031,0.0001720032,0.0003631781,0.0001474551,0.0002088164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009016031,0.0002244239,0.005347528,0.00005123333,0.0001217506,0.00002776872,0.0002879506,0.0009308457,0.9864265,0.00001957173,0.000005450117,0.005655391],"study_design_scores_gemma":[0.002820677,0.0002192364,0.006442115,0.0001662214,0.0001405732,0.00001882768,0.0004499663,0.01629112,0.9730882,0.00001648762,0.00005411817,0.0002924654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871826,0.004547716,0.007275666,0.00007639234,0.00003347224,0.0006183484,0.0001981645,0.00001116676,0.00005649969],"genre_scores_gemma":[0.999108,0.00007823422,0.0005265536,0.00007600205,0.0000337665,0.00003753539,0.00007845356,0.0000462004,0.00001521699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01536027,"threshold_uncertainty_score":0.9999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005901399655021413,"score_gpt":0.2114267623141207,"score_spread":0.2055253626590993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}