{"id":"W2909077566","doi":"10.1016/j.dmpk.2018.09.227","title":"Effects of mycophenolic acid and clinical variables on tacrolimus exposure in de novo, steroid-free adult renal transplant patients","year":2019,"lang":"en","type":"article","venue":"Drug Metabolism and Pharmacokinetics","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Alberta","funders":"","keywords":"Tacrolimus; Mycophenolic acid; Renal transplant; Mycophenolate; Medicine; Steroid; Internal medicine; Pharmacology; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003281163,0.0001942187,0.0004598693,0.0002466899,0.0002351347,0.0006334324,0.0001521047,0.0003670821,0.001369106],"category_scores_gemma":[0.001746266,0.0001273531,0.0006566325,0.0004136299,0.0002066282,0.0004983473,0.0003129125,0.000705804,0.0001423531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002707044,"about_ca_system_score_gemma":0.0002796212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001778537,"about_ca_topic_score_gemma":0.002216497,"domain_scores_codex":[0.999752,0.00006908771,0.00003254012,0.00005107323,0.00003613344,0.00005921616],"domain_scores_gemma":[0.9988426,0.0004138085,0.000388643,0.00005731161,0.00004733241,0.0002502636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004187012,0.0002226791,0.9904402,0.00001535498,0.0002275622,0.0002103306,0.00007954903,0.0001136869,0.0006199088,0.00004052708,0.00007983403,0.003763331],"study_design_scores_gemma":[0.00004060175,0.0007813943,0.998022,0.000004645153,0.0001037348,0.000245527,0.0001324104,0.0003729662,0.0001267996,0.00004522693,0.0001193585,0.00000543603],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994578,0.0002094325,0.00002201959,0.00002417493,0.000003763832,0.000001670479,0.00005652307,0.00000125878,0.0002233555],"genre_scores_gemma":[0.999686,0.00006824375,0.00002372533,0.00002204903,0.00001078662,0.000001634923,0.00008501727,7.501774e-7,0.0001017816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001778537,"threshold_uncertainty_score":0.00458014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008024519976537792,"score_gpt":0.2776367913411653,"score_spread":0.2696122713646275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}