{"id":"W2909115119","doi":"10.1074/jbc.ra118.004825","title":"CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Fondation Brain Canada; ALS Society of Canada","keywords":"SOD1; Superoxide dismutase; Cell biology; Extracellular; Extracellular vesicles; Chemistry; Vesicle; Superoxide; Biology; Biochemistry; Enzyme; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169298,0.0003773229,0.000355253,0.0003528584,0.0002541181,0.0003936274,0.0001505836,0.0003218404,0.0007598777],"category_scores_gemma":[0.0001582769,0.0001229553,0.0003444921,0.0001692512,0.0001645255,0.0003175137,0.0003971936,0.0006959494,0.0004869064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001545239,"about_ca_system_score_gemma":0.0001245367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002312031,"about_ca_topic_score_gemma":0.0004385637,"domain_scores_codex":[0.9998753,0.00001478593,0.00001767116,0.00002842185,0.00003296307,0.00003083722],"domain_scores_gemma":[0.9998364,0.00003548459,0.00004130047,0.00002089775,0.00003037799,0.00003539844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001127357,0.00001047634,0.0003812379,0.00004607679,0.00001253811,0.0001320051,0.00003245176,0.00004158909,0.9980409,0.0002633904,0.00004123212,0.0008853516],"study_design_scores_gemma":[0.00001178179,0.00008291666,0.007453826,0.00002155052,0.00003654523,0.001209713,0.00008143708,0.0005247316,0.9853532,0.0003974659,0.004817015,0.000009859991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981822,0.001943434,0.01130902,0.0001509837,0.0001232471,0.0000550625,0.001949461,0.0001150088,0.002531867],"genre_scores_gemma":[0.9865045,0.0009697847,0.00625764,0.00006033037,0.00002375171,0.00004916833,0.003116845,0.00009091224,0.002926981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007598777,"threshold_uncertainty_score":0.002542019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037061377804904,"score_gpt":0.2260155077919034,"score_spread":0.2156448940138543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}