{"id":"W2909163269","doi":"10.2196/11545","title":"TheraSphere Yttrium-90 Glass Microspheres Combined With Chemotherapy Versus Chemotherapy Alone in Second-Line Treatment of Patients With Metastatic Colorectal Carcinoma of the Liver: Protocol for the EPOCH Phase 3 Randomized Clinical Trial","year":2019,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Research UK; Moffitt Cancer Center; Johns Hopkins University; Emory University; Massachusetts General Hospital","keywords":"Medicine; Oxaliplatin; Irinotecan; Regimen; Internal medicine; Clinical endpoint; Colorectal cancer; Oncology; Chemotherapy; Chemotherapy regimen; Randomized controlled trial; Progression-free survival; Response Evaluation Criteria in Solid Tumors; Progressive disease; Cancer; Surgery","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01092369,0.005011047,0.005501554,0.001026804,0.00119754,0.0020786,0.002610922,0.004060548,0.01997076],"category_scores_gemma":[0.007200211,0.001545913,0.00352383,0.001504923,0.001770364,0.001673886,0.001255129,0.004910352,0.003094696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002396088,"about_ca_system_score_gemma":0.007095478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001731843,"about_ca_topic_score_gemma":0.004600766,"domain_scores_codex":[0.9955289,0.002936516,0.0002574317,0.000352592,0.0003671912,0.0005574839],"domain_scores_gemma":[0.9965238,0.0006944301,0.001091806,0.0003444145,0.0004703814,0.0008750549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9867977,0.005412782,0.0002133651,0.0008409244,0.0005052075,0.00003143271,0.00003435337,0.0004691045,0.001039499,0.0001734828,0.001555489,0.002926426],"study_design_scores_gemma":[0.9633259,0.03226584,0.0004802084,0.00008022096,0.0003083048,0.00001811197,0.00001713738,0.0005273568,0.0002643975,0.0002418539,0.002453581,0.00001702871],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1922407,0.003722537,0.004566257,0.001949186,0.002451394,0.7744824,0.01171522,0.00052644,0.008345847],"genre_scores_gemma":[0.1485449,0.002839591,0.009322101,0.002866324,0.0007342154,0.8239116,0.004028728,0.0000726946,0.007679894],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01997076,"threshold_uncertainty_score":0.06680882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2317552702615926,"score_gpt":0.4834972302988182,"score_spread":0.2517419600372256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}