{"id":"W2909163269","doi":"10.2196/11545","title":"TheraSphere Yttrium-90 Glass Microspheres Combined With Chemotherapy Versus Chemotherapy Alone in Second-Line Treatment of Patients With Metastatic Colorectal Carcinoma of the Liver: Protocol for the EPOCH Phase 3 Randomized Clinical Trial","year":2019,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Research UK; Moffitt Cancer Center; Johns Hopkins University; Emory University; Massachusetts General Hospital","keywords":"Medicine; Oxaliplatin; Irinotecan; Regimen; Internal medicine; Clinical endpoint; Colorectal cancer; Oncology; Chemotherapy; Chemotherapy regimen; Randomized controlled trial; Progression-free survival; Response Evaluation Criteria in Solid Tumors; Progressive disease; Cancer; Surgery","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00239109,0.0004545228,0.001782536,0.0001056573,0.0001276878,0.00004746698,0.0004239347,0.0001764847,0.0008309791],"category_scores_gemma":[0.0001506885,0.0001940978,0.0006027169,0.0006753656,0.0008592389,0.00009605043,0.00005030337,0.0003897228,0.000005670589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002235696,"about_ca_system_score_gemma":0.0009819382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001242173,"about_ca_topic_score_gemma":0.0001759159,"domain_scores_codex":[0.9949217,0.001635274,0.001168985,0.0005981611,0.001052805,0.000623025],"domain_scores_gemma":[0.9939085,0.003584297,0.0006370459,0.0009354787,0.0007840221,0.0001506973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7944866,0.01575084,0.1804377,0.0006182668,0.0009925191,0.00001094022,0.0005415108,7.978896e-7,0.0004011556,0.00002476363,0.0001312781,0.006603581],"study_design_scores_gemma":[0.8321728,0.1159527,0.01124499,0.0005805114,0.00009655538,0.00000173657,0.0001037309,0.0007656419,0.03508167,0.00002443141,0.00379253,0.0001826956],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.4883867,0.000009435329,0.000007608712,0.0001713818,0.000009016913,0.511308,0.00003731635,0.000009790559,0.0000608223],"genre_scores_gemma":[0.3702184,0.000002234721,0.0003813212,0.00002025208,0.00005163897,0.6289282,0.0000256441,0.0000576372,0.0003147032],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1691927,"threshold_uncertainty_score":0.9098639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2317552702615926,"score_gpt":0.4834972302988182,"score_spread":0.2517419600372256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}