{"id":"W2909242954","doi":"10.1002/ana.25410","title":"Amyloid‐β immunotherapy for alzheimer disease: Is it now a long shot?","year":2019,"lang":"en","type":"review","venue":"Annals of Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Care Foundation","funders":"Genentech; Biogen; Eli Lilly and Company","keywords":"Disease; Immunotherapy; Medicine; Clinical trial; Amyloid β; Pathological; Neuroscience; Alzheimer's disease; Amyloid (mycology); Psychology; Immunology; Pathology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005506381,0.0006371217,0.001195653,0.001404899,0.0002614811,0.001042555,0.0007379745,0.001031077,0.005003381],"category_scores_gemma":[0.0006863013,0.0001642963,0.0004378487,0.001424648,0.0004496588,0.00138647,0.00050721,0.002161894,0.002983809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004345632,"about_ca_system_score_gemma":0.0007215099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007174418,"about_ca_topic_score_gemma":0.001816013,"domain_scores_codex":[0.9998748,0.00002896768,0.00001621466,0.00001662584,0.00005011238,0.00001326874],"domain_scores_gemma":[0.9997346,0.0001278587,0.00003144022,0.00001037827,0.00006613792,0.00002958057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007868876,0.00006606855,0.0000701036,0.009413822,0.00005707242,0.00008715611,0.00004643594,0.0001269165,0.0006332188,0.002716223,0.04889249,0.9378119],"study_design_scores_gemma":[0.00002850289,0.0001009165,0.0005367919,0.005570658,0.0001019274,0.000779603,0.00006707566,0.00005345959,0.0001818277,0.002882793,0.989684,0.00001237827],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000459953,0.9988921,0.00003330292,0.0003863316,0.0002107075,0.000001525243,0.00000620324,0.00000496538,0.0004188203],"genre_scores_gemma":[0.0004122859,0.9984279,0.00009267355,0.0002963145,0.0002255416,0.000003458312,0.00001306333,0.000001322824,0.0005274122],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005003381,"threshold_uncertainty_score":0.016738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2961999565018312,"score_gpt":0.4783524148652205,"score_spread":0.1821524583633893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}