{"id":"W2909242954","doi":"10.1002/ana.25410","title":"Amyloid‐β immunotherapy for alzheimer disease: Is it now a long shot?","year":2019,"lang":"en","type":"review","venue":"Annals of Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Care Foundation","funders":"Genentech; Biogen; Eli Lilly and Company","keywords":"Disease; Immunotherapy; Medicine; Clinical trial; Amyloid β; Pathological; Neuroscience; Alzheimer's disease; Amyloid (mycology); Psychology; Immunology; Pathology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001912543,0.0005831176,0.002492244,0.0003558109,0.00006248527,0.00001610024,0.0003649529,0.0003856267,0.0006717424],"category_scores_gemma":[0.00006612383,0.0004437056,0.001751905,0.0002287209,0.000208577,0.0000708248,0.00009755203,0.0004085368,0.0006020541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009036482,"about_ca_system_score_gemma":0.000930629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001084805,"about_ca_topic_score_gemma":0.000001525267,"domain_scores_codex":[0.9970501,0.0002202217,0.0007206049,0.0007965569,0.0004160706,0.0007964673],"domain_scores_gemma":[0.9971358,0.0005066982,0.000413076,0.001111742,0.000315938,0.0005167941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004130009,0.001605569,0.0005619569,0.01593521,0.05413667,0.0008140819,0.00002991586,3.15311e-7,5.762728e-7,0.00006462762,0.1154884,0.8072327],"study_design_scores_gemma":[0.001266713,0.002010019,0.000459474,0.001438219,0.006827717,0.00007243331,8.737604e-7,0.000007795628,0.000005884221,0.00007641973,0.9875644,0.0002700507],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005971895,0.9889052,0.000004571617,0.006089881,0.0001976605,0.003357451,0.0009058348,0.00003052233,0.0004491876],"genre_scores_gemma":[0.0002201749,0.9893299,0.00001647563,0.008345224,0.0002360611,0.0005128583,0.0007298074,0.0001501605,0.0004593713],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.872076,"threshold_uncertainty_score":0.9998015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2961999565018312,"score_gpt":0.4783524148652205,"score_spread":0.1821524583633893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}