{"id":"W2909283569","doi":"10.1101/524793","title":"Direct binding of the flexible C-terminal segment of periaxin to β4 integrin suggests a molecular basis for CMT4F","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Biocenter, University of Oulu; Norges Forskningsråd; Universitetet i Bergen; Wellcome Trust; European Synchrotron Radiation Facility; Deutsches Elektronen-Synchrotron","keywords":"Basal lamina; Cell biology; Dystroglycan; Cytoplasm; Fibronectin; Schwann cell; Integrin; Biology; Cytoskeleton; Myelin; Cell; Extracellular matrix; Laminin; Biochemistry; Anatomy; Neuroscience; Ultrastructure; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006343087,0.0005681197,0.0008493835,0.0003165413,0.0001038703,0.00007178455,0.001619392,0.0003964507,0.0000624614],"category_scores_gemma":[0.002982016,0.0004697502,0.0004353925,0.0008498602,0.0002271947,0.00009349909,0.001229162,0.0005917958,0.00003057511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001733736,"about_ca_system_score_gemma":0.000514439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003835954,"about_ca_topic_score_gemma":0.000001745104,"domain_scores_codex":[0.9961349,0.0004029785,0.0007750366,0.001344378,0.0006800127,0.0006627067],"domain_scores_gemma":[0.9967781,0.0004542709,0.0005946323,0.001693272,0.000263961,0.0002157292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001166653,0.0002009496,0.001941082,0.0005857761,0.0000325424,0.00002003167,0.00002213532,0.001037187,0.9955581,0.0003406164,0.0001412609,0.000003602431],"study_design_scores_gemma":[0.0003527938,0.0002852062,0.01502063,0.0004945529,0.00007421414,3.239992e-8,0.000004262258,0.0003148417,0.9817811,0.000002858541,0.001218815,0.0004507478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933585,0.00008632379,0.001067893,0.0003634509,0.001541322,0.002490802,0.0009025843,0.0001407278,0.00004842426],"genre_scores_gemma":[0.997332,0.00003403283,0.001496572,0.000549048,0.00007524133,0.0003852333,1.321916e-7,0.0001128,0.0000148796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01377711,"threshold_uncertainty_score":0.9997754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02543680595616818,"score_gpt":0.2509257884791723,"score_spread":0.2254889825230041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}