{"id":"W2909315094","doi":"10.15252/embj.2018100330","title":"Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer","year":2019,"lang":"en","type":"review","venue":"The EMBO Journal","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"BC Cancer Foundation; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Breast cancer; Phenotype; Human breast; Biology; Mammary gland; Cancer; Cell; Mammary tumor; Cancer research; Computational biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003817615,0.000632246,0.001101021,0.001554683,0.0001890129,0.0007740197,0.0006553864,0.0007903584,0.002152828],"category_scores_gemma":[0.000335534,0.0002721274,0.0002831295,0.001690909,0.0004895908,0.0008002379,0.0005836597,0.001031601,0.002272348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005844638,"about_ca_system_score_gemma":0.0007510132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006567001,"about_ca_topic_score_gemma":0.0009433347,"domain_scores_codex":[0.9998826,0.00001538349,0.00001725769,0.00003017024,0.0000385628,0.00001596591],"domain_scores_gemma":[0.9998561,0.00006004295,0.0000212349,0.000005653586,0.00004092372,0.00001610695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001302438,0.00005775716,0.0002455957,0.01584694,0.0000547951,0.0002255596,0.00009297522,0.0005277759,0.01083078,0.004760032,0.01464563,0.9525818],"study_design_scores_gemma":[0.00001392429,0.0001250505,0.00141878,0.001772962,0.00007358739,0.001218317,0.00007490307,0.0001013199,0.002695223,0.002252761,0.9902287,0.00002448382],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001878051,0.9987389,0.000138039,0.0001037713,0.00007660547,0.000003241485,0.0000229258,0.000006469898,0.0007221935],"genre_scores_gemma":[0.0009161109,0.9983056,0.0001339189,0.00008098475,0.00006270286,0.000005307967,0.00004617894,0.000001469408,0.0004476365],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002152828,"threshold_uncertainty_score":0.00720191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06312263952245081,"score_gpt":0.3373038489096586,"score_spread":0.2741812093872078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}