{"id":"W2909325558","doi":"10.1016/j.dmpk.2018.09.182","title":"Characterising the immune response to carbamazepine: Understanding the development of idiosyncratic drug reactions","year":2019,"lang":"en","type":"article","venue":"Drug Metabolism and Pharmacokinetics","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Carbamazepine; Drug; Immune system; Medicine; Pharmacology; Immunology; Psychiatry; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001290311,0.0004003213,0.0005232797,0.0007048223,0.0001055749,0.0006768794,0.0002554517,0.0005167127,0.0005938493],"category_scores_gemma":[0.001794688,0.0001437992,0.0003618357,0.0003253676,0.0003653975,0.0005530495,0.000214389,0.000590604,0.0001395788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002410238,"about_ca_system_score_gemma":0.0001968174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003751349,"about_ca_topic_score_gemma":0.0003741532,"domain_scores_codex":[0.999416,0.0002583048,0.00005134509,0.00007074663,0.0001406621,0.00006291645],"domain_scores_gemma":[0.9990811,0.0003563634,0.0003127207,0.00007738986,0.0001083259,0.00006401879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002497199,0.000443577,0.2343499,0.000712542,0.0002751687,0.00244404,0.0004426948,0.002093864,0.5472102,0.0006417859,0.0003699342,0.2085192],"study_design_scores_gemma":[0.0001542239,0.007609769,0.6269693,0.0001907604,0.0005249556,0.0204825,0.0007926907,0.009988825,0.3197963,0.00161859,0.01181772,0.00005430056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770907,0.01412211,0.006508752,0.0002910845,0.00002478975,0.00008509414,0.00007093146,0.00003333228,0.00177327],"genre_scores_gemma":[0.9936139,0.003901597,0.001699988,0.0002599825,0.00005571552,0.00002317007,0.00007937199,0.000007946214,0.0003583818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290311,"threshold_uncertainty_score":0.006823897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03085651954600625,"score_gpt":0.3075934172434556,"score_spread":0.2767368976974493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}