{"id":"W2909335073","doi":"10.1016/j.metabol.2019.01.004","title":"Does metformin therapy influence the effects of intensive lifestyle intervention? Exploring the interaction between first line therapies in the Look AHEAD trial","year":2019,"lang":"en","type":"article","venue":"Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Ottawa","funders":"National Institute on Minority Health and Health Disparities; Office of Research on Women's Health; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Nursing Research; Centers for Disease Control and Prevention","keywords":"Metformin; Medicine; Type 2 diabetes; Diabetes mellitus; Internal medicine; Glycated hemoglobin; Body mass index; Randomized controlled trial; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001010408,0.0002191754,0.0003433103,0.00006089294,0.0001044387,0.00005802657,0.000621762,0.00008658705,0.00002530376],"category_scores_gemma":[0.0004709139,0.00008537465,0.0002600756,0.0001969109,0.0001406945,0.00003718099,0.0001096799,0.0002713727,0.00001076521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008717652,"about_ca_system_score_gemma":0.00003037607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001960712,"about_ca_topic_score_gemma":0.0001181363,"domain_scores_codex":[0.9983103,0.0004801276,0.0004240795,0.0002875591,0.000246589,0.0002513897],"domain_scores_gemma":[0.998453,0.0003846887,0.0002480223,0.0006715569,0.0002170919,0.00002565548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006972619,0.0005351788,0.01566867,0.0003110262,0.00140389,0.00000323323,0.02156715,0.0002265325,0.06162753,0.000859845,0.001110399,0.8897139],"study_design_scores_gemma":[0.0142548,0.0007015805,0.04774735,0.0001716807,0.0001680843,0.00000255171,0.005057966,0.00001358858,0.2944336,0.0008464206,0.6362676,0.0003347277],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9221033,0.07448145,0.00003732162,0.0003257116,0.001972597,0.001030104,0.000009078005,0.00000738194,0.00003306911],"genre_scores_gemma":[0.9582813,0.03897768,0.00001223279,0.0009963885,0.001146084,0.0004314481,0.00001741121,0.00002176717,0.0001156895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8893792,"threshold_uncertainty_score":0.3481477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174390013268005,"score_gpt":0.2786233234093879,"score_spread":0.2611843220825874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}