{"id":"W2909461542","doi":"10.1101/lm.048660.118","title":"Noradrenergic stabilization of heterosynaptic LTP requires activation of Epac in the hippocampus","year":2019,"lang":"en","type":"article","venue":"Learning & Memory","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Long-term potentiation; Chemistry; Synaptic plasticity; Neuroscience; Excitatory postsynaptic potential; Hippocampal formation; Hippocampus; LTP induction; Stimulation; Neurotransmission; Postsynaptic potential; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005694343,0.00008855947,0.0001595299,0.0001974218,0.00007236628,0.00001489142,0.0003944702,0.00004014581,0.00008345042],"category_scores_gemma":[0.001273377,0.0000674313,0.00004326024,0.000743039,0.0002433473,0.0002453826,0.00007204247,0.0003414685,0.00002432014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001763038,"about_ca_system_score_gemma":0.00005125639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000152847,"about_ca_topic_score_gemma":0.000001502704,"domain_scores_codex":[0.9978684,0.0009047319,0.0002522663,0.0003094,0.0004353295,0.0002299282],"domain_scores_gemma":[0.9984999,0.001014489,0.0001883013,0.0002381247,0.00003474549,0.00002446201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006396347,0.00007877759,0.01555302,0.00005020723,7.101083e-7,0.000006416102,0.000760568,0.008860934,0.9732334,0.0000923956,0.000007410804,0.001292188],"study_design_scores_gemma":[0.0003958704,0.0003410513,0.01395967,0.00003206392,0.0000032605,0.000008050226,0.0002093907,0.003842306,0.9809104,0.0001934777,0.0000382392,0.0000662427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988067,0.00001210403,0.00001420926,0.0002468786,0.0001733507,0.000286964,7.602899e-7,0.00001890489,0.0004401037],"genre_scores_gemma":[0.9994357,0.00005535852,0.000004622098,0.0002813166,0.00001591866,0.00001013174,5.744595e-7,0.00001131116,0.0001850993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007676967,"threshold_uncertainty_score":0.2749768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03749939666269355,"score_gpt":0.3189893368027122,"score_spread":0.2814899401400187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}