{"id":"W2909468141","doi":"10.1016/j.bbrc.2019.01.024","title":"Overexpression of Interleukin-15 exhibits improved glucose tolerance and promotes GLUT4 translocation via AMP-Activated protein kinase pathway in skeletal muscle","year":2019,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto; University of New Brunswick","funders":"Japan Society for the Promotion of Science; Osaka Medical Research Foundation for Intractable Diseases; Food Science Institute Foundation","keywords":"Skeletal muscle; GLUT4; Myokine; Internal medicine; Endocrinology; Glucose uptake; AMPK; Carbohydrate metabolism; Glucose transporter; AMP-activated protein kinase; Biology; Insulin resistance; Snf3; Protein kinase A; Insulin; Phosphorylation; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002957469,0.0001369223,0.0002258275,0.0001292322,0.0001307341,0.00002123115,0.000286868,0.000200803,0.00009507689],"category_scores_gemma":[0.0001624462,0.000114864,0.00005249411,0.0003090364,0.0005458222,0.000168998,0.0002465665,0.0006910014,0.00005275595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004500473,"about_ca_system_score_gemma":0.00004821331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000358304,"about_ca_topic_score_gemma":0.00001913473,"domain_scores_codex":[0.9986615,0.0003722475,0.0003200487,0.0003061508,0.00008001873,0.00026009],"domain_scores_gemma":[0.9988213,0.0002638227,0.00008386643,0.0005917968,0.0001970479,0.0000421784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002105032,0.0006608485,0.00003456192,0.00007232902,0.00001452775,7.898441e-8,0.0003056224,6.606147e-8,0.9823799,0.0002643262,0.00006766595,0.01598958],"study_design_scores_gemma":[0.0009422221,0.0002948899,0.00182,0.0003455494,0.000002576962,0.000002468406,0.0001243201,0.0003041427,0.989157,0.0001547924,0.006726743,0.0001253183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965941,0.001830651,0.0000295378,0.0005815327,0.00004974574,0.0006786957,0.000009813767,0.00002406442,0.0002019071],"genre_scores_gemma":[0.9988124,0.0002265052,0.0001597705,0.00002119275,0.00001046875,0.0001003239,0.0001767717,0.00001115283,0.0004814182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01586426,"threshold_uncertainty_score":0.4684016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02779445072290416,"score_gpt":0.2956817813983084,"score_spread":0.2678873306754043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}