{"id":"W2909510792","doi":"10.1007/s00438-018-01529-5","title":"A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7","year":2019,"lang":"en","type":"article","venue":"Molecular Genetics and Genomics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche","keywords":"Biology; Gene knockdown; RNA interference; mTORC1; Ubiquitin ligase; Cell biology; Enhancer; Protein subunit; F-box protein; P70-S6 Kinase 1; Gene; Phosphorylation; Ubiquitin; Genetics; RNA; Gene expression; Protein kinase B","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002240851,0.0002223554,0.0002084162,0.0000649018,0.0001011954,0.00006315496,0.0003776141,0.0001500495,0.00001055926],"category_scores_gemma":[0.0000460114,0.0001931971,0.0001534753,0.00007176685,0.0001584733,0.000003529182,0.0002626946,0.00009235927,0.000005967316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000924563,"about_ca_system_score_gemma":0.00007154237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003155783,"about_ca_topic_score_gemma":0.00003113901,"domain_scores_codex":[0.9986823,0.00007440176,0.0003458925,0.0004236003,0.0001874571,0.0002863485],"domain_scores_gemma":[0.998987,0.00002246385,0.0001608141,0.0005800427,0.0001586064,0.00009108282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000899923,0.00003969794,0.001478564,0.00005988321,0.00009477895,0.000001644577,0.0001178762,0.0003735524,0.9955014,0.0007494752,0.0002065488,0.001286611],"study_design_scores_gemma":[0.0009011432,0.0004234877,0.004115149,0.00001331431,0.00006647105,0.00001659221,0.000131134,0.0005428257,0.9828987,0.002957244,0.007643468,0.000290464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988566,0.003458676,0.006313126,0.0002407906,0.0001825107,0.0008724045,0.0001266852,0.000007455631,0.0002323257],"genre_scores_gemma":[0.9953622,0.000925946,0.002684668,0.0003241557,0.0001090578,0.00004459159,0.0001334413,0.00005270334,0.0003632552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01260267,"threshold_uncertainty_score":0.7878349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006194428395646264,"score_gpt":0.2145829298435205,"score_spread":0.2083885014478742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}