{"id":"W2909533581","doi":"10.1016/j.eururo.2019.01.009","title":"Randomized Phase 1 Trial of Pembrolizumab with Sequential Versus Concomitant Stereotactic Body Radiotherapy in Metastatic Urothelial Carcinoma","year":2019,"lang":"en","type":"letter","venue":"European Urology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Concomitant; Pembrolizumab; Radiation therapy; Adverse effect; Oncology; Common Terminology Criteria for Adverse Events; Internal medicine; Tolerability; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001528985,0.0007328475,0.001964009,0.0001994785,0.0004845423,0.0008392132,0.0007676496,0.002981405,0.006933977],"category_scores_gemma":[0.00261376,0.0004328912,0.001038542,0.000248387,0.0007130883,0.0008509353,0.0002715059,0.003905643,0.0009587776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001507794,"about_ca_system_score_gemma":0.001062264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001178885,"about_ca_topic_score_gemma":0.003537928,"domain_scores_codex":[0.9994766,0.0003084714,0.00002814097,0.00008746635,0.00003025987,0.00006910124],"domain_scores_gemma":[0.998609,0.0007371598,0.000184674,0.00006026751,0.00005657156,0.0003524514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9361652,0.00424713,0.001093652,0.0005498997,0.00111888,0.000234543,0.00007001274,0.0007204115,0.002689922,0.0004153629,0.01371093,0.03898418],"study_design_scores_gemma":[0.9486206,0.0404482,0.002468291,0.0000698435,0.0005737493,0.0001276794,0.00003358986,0.00103406,0.0004813653,0.0006738035,0.005450798,0.00001794234],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9224154,0.01329419,0.00116015,0.03927862,0.008035993,0.002546998,0.002625636,0.0002184482,0.01042442],"genre_scores_gemma":[0.9625599,0.002653836,0.001857097,0.02072126,0.002204737,0.002106481,0.0009625817,0.00004080257,0.006893257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006933977,"threshold_uncertainty_score":0.02319652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03970726362905173,"score_gpt":0.316673709177014,"score_spread":0.2769664455479623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}