{"id":"W2909575449","doi":"10.1002/path.5232","title":"The immunological consequences of radiation‐induced DNA damage","year":2019,"lang":"en","type":"review","venue":"The Journal of Pathology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Cancer Research UK; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Royal Marsden NHS Foundation Trust","keywords":"Immune system; DNA damage; Cancer research; Biology; Stromal cell; Genome instability; Stimulator of interferon genes; Abscopal effect; Context (archaeology); Radiation therapy; Tumor microenvironment; DNA repair; Immunosuppression; Interferon; Immunology; Programmed cell death; Immunotherapy; Innate immune system; Apoptosis; Medicine; DNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002689844,0.0003033823,0.001724257,0.000188309,0.0002237555,0.00001304819,0.001472241,0.0006523223,0.0002545822],"category_scores_gemma":[0.0008895633,0.0001261735,0.0006512975,0.0001508765,0.001396954,0.00004976974,0.0001880337,0.001423275,0.0003815017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005752833,"about_ca_system_score_gemma":0.0005914742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006394705,"about_ca_topic_score_gemma":0.000001350866,"domain_scores_codex":[0.9928188,0.005264929,0.001380197,0.000130712,0.00006093547,0.0003444286],"domain_scores_gemma":[0.9931471,0.003711111,0.002382311,0.0005658392,0.000180978,0.00001262173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007158307,0.00009278925,0.000002251223,0.0004833737,0.001325104,0.00008249061,0.0004574078,3.927352e-7,0.09859957,0.001865357,0.0018563,0.8945192],"study_design_scores_gemma":[0.0005041434,0.001430005,0.00005178125,0.001093675,0.0009924565,0.01167132,0.0003560744,3.451719e-8,0.009992808,0.000129567,0.9736185,0.0001596496],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007101139,0.989178,0.00001212065,0.0002629908,0.002688643,0.0003061144,0.00002269682,0.000007114073,0.0004211971],"genre_scores_gemma":[0.007687829,0.9905248,0.000005770939,0.000052606,0.0000580205,0.000005079717,0.00001001226,0.00001927681,0.001636627],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9717622,"threshold_uncertainty_score":0.6183502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06573877676198982,"score_gpt":0.3392989804406493,"score_spread":0.2735602036786595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}