{"id":"W2909590336","doi":"10.1182/blood-2018-99-118238","title":"Tocilizumab to Prevent Infusion-Related Events in Patients with Chronic Lymphocytic Leukemia and Co-Morbidities Treated with Obinutuzumab and Chlorambucil: Results from the Randomized Phase Ib GALACTA Trial","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Medicine; Obinutuzumab; Internal medicine; Tolerability; Chlorambucil; Neutropenia; Chronic lymphocytic leukemia; Population; Gastroenterology; Placebo; Rituximab; Pharmacology; Adverse effect; Leukemia; Cyclophosphamide; Toxicity; Chemotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001216543,0.0007086617,0.001348908,0.0002078807,0.0002134925,0.001021414,0.0004633898,0.0007959893,0.001988161],"category_scores_gemma":[0.001227144,0.0002569533,0.001811356,0.0002942844,0.0004744683,0.000479744,0.0003266185,0.00208488,0.0003533584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008797529,"about_ca_system_score_gemma":0.0006412226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090148,"about_ca_topic_score_gemma":0.002574283,"domain_scores_codex":[0.9995281,0.0002633081,0.00002701639,0.00006480857,0.00004332608,0.00007339706],"domain_scores_gemma":[0.9993272,0.0001539325,0.0002050748,0.00004271593,0.00003539313,0.0002358295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9290648,0.00362213,0.008749569,0.0007315651,0.003531675,0.00007131841,0.00007206948,0.0004894381,0.003595584,0.0001653309,0.001880959,0.04802541],"study_design_scores_gemma":[0.8865959,0.07252076,0.0327937,0.0001781535,0.00355593,0.0001904903,0.00006627711,0.0008770195,0.0007254193,0.0003058701,0.002162465,0.00002791008],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984009,0.012105,0.0001736293,0.0007426898,0.0001877082,0.0005127151,0.0007121715,0.00004157062,0.001515547],"genre_scores_gemma":[0.9932215,0.002949531,0.0003924112,0.0008281152,0.0002263257,0.0005860299,0.001092085,0.000008505674,0.000695403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001988161,"threshold_uncertainty_score":0.006651103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119566306881662,"score_gpt":0.2743807633454712,"score_spread":0.262424132657305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}