{"id":"W2909590336","doi":"10.1182/blood-2018-99-118238","title":"Tocilizumab to Prevent Infusion-Related Events in Patients with Chronic Lymphocytic Leukemia and Co-Morbidities Treated with Obinutuzumab and Chlorambucil: Results from the Randomized Phase Ib GALACTA Trial","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Medicine; Obinutuzumab; Internal medicine; Tolerability; Chlorambucil; Neutropenia; Chronic lymphocytic leukemia; Population; Gastroenterology; Placebo; Rituximab; Pharmacology; Adverse effect; Leukemia; Cyclophosphamide; Toxicity; Chemotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008399466,0.0004610164,0.001077407,0.0001994176,0.0002059476,0.0000638504,0.0002227263,0.0002144149,0.00009277271],"category_scores_gemma":[0.0008533527,0.0002598836,0.0000782725,0.0005163947,0.0007208394,0.000158455,0.0001706826,0.0003128303,0.00002881901],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.02144177,"about_ca_system_score_gemma":0.01585825,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01149059,"about_ca_topic_score_gemma":0.00124542,"domain_scores_codex":[0.9963366,0.0003914794,0.0008235374,0.0008301387,0.0009636972,0.0006545207],"domain_scores_gemma":[0.9973144,0.001013301,0.0002552827,0.0008161209,0.0002396322,0.0003612471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9928483,0.0007768451,0.0009590941,0.00006479143,0.0008186412,0.0001084472,0.00263137,0.00002315402,0.0001037862,0.000007706823,0.0002981767,0.001359728],"study_design_scores_gemma":[0.9783871,0.008568873,0.005385777,0.001040693,0.0007226476,0.00006723856,0.0001166552,0.003203632,0.002015247,0.00003042843,0.0001280632,0.0003336991],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919224,0.0003725185,0.000003023822,0.0001001323,0.00006673129,0.006891385,0.0001343851,0.00008072591,0.0004287108],"genre_scores_gemma":[0.9981695,0.0001466525,0.00007011337,0.00009816017,0.0002349087,0.0003454673,0.0003312536,0.00006673294,0.0005371645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01446121,"threshold_uncertainty_score":0.9999853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119566306881662,"score_gpt":0.2743807633454712,"score_spread":0.262424132657305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}