{"id":"W2909608150","doi":"10.1016/j.abb.2019.01.018","title":"Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3","year":2019,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University of Ottawa","keywords":"UCP3; Skeletal muscle; Mitochondrial ROS; Uncoupling protein; Reactive oxygen species; Superoxide; Mitochondrion; Biophysics; Respiration; Catalase; Chemistry; Oxidative phosphorylation; Biochemistry; Depolarization; Cell biology; Inner mitochondrial membrane; Biology; Oxidative stress; Anatomy; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003095085,0.0002855128,0.0001986072,0.0002586591,0.0003711531,0.000436051,0.0003223932,0.0004698206,0.00122497],"category_scores_gemma":[0.0003253741,0.000193418,0.0001576827,0.0001707041,0.0004646128,0.0006282976,0.0003757055,0.0005172932,0.000163341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000455118,"about_ca_system_score_gemma":0.0003476554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002460775,"about_ca_topic_score_gemma":0.003844907,"domain_scores_codex":[0.999929,0.00001575507,0.000005837026,0.00001357276,0.00001718486,0.00001865493],"domain_scores_gemma":[0.9997852,0.00006589561,0.00004921004,0.00001898476,0.00002887333,0.00005183533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00481866,0.0000660018,0.003215864,0.000109791,0.0000299329,0.0003526034,0.0001032253,0.0001476204,0.9855854,0.0009022585,0.0001328827,0.004535714],"study_design_scores_gemma":[0.0003253867,0.001718801,0.1712199,0.00006502317,0.0001239393,0.001213979,0.0007306079,0.003472205,0.8147767,0.001986113,0.004339184,0.00002826282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789693,0.01338215,0.002672481,0.0006667985,0.00004618796,0.00001974539,0.0002729461,0.00004841569,0.00392187],"genre_scores_gemma":[0.9961808,0.001131612,0.0007086113,0.00007752463,0.00001026734,0.000007190992,0.00009999193,0.000008477999,0.001775591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002460775,"threshold_uncertainty_score":0.004892886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002831579465803258,"score_gpt":0.1867972099866823,"score_spread":0.183965630520879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}