{"id":"W2909759607","doi":"10.1002/chem.201805919","title":"Evaluation of 1,2,3‐Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX‐770 and VX‐809","year":2019,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Ryerson University; National Institutes of Health; Vanderbilt University; Cystic Fibrosis Foundation","keywords":"Potentiator; Cystic fibrosis transmembrane conductance regulator; Bioisostere; Chemistry; Triazole; Amide; Transmembrane protein; Regulator; Biophysics; Pharmacology; Biochemistry; Medicine; In vitro; Biology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003069168,0.0002859781,0.0004420491,0.000251708,0.0001461104,0.0003372792,0.0003393597,0.0003850554,0.001446664],"category_scores_gemma":[0.0002431804,0.0001424443,0.0003174071,0.0002402689,0.0001629168,0.0002695889,0.0001882679,0.0007291982,0.0002862402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002361221,"about_ca_system_score_gemma":0.0002430768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005892352,"about_ca_topic_score_gemma":0.00147917,"domain_scores_codex":[0.9998544,0.00003858353,0.00001555632,0.00002288625,0.00003972263,0.00002870817],"domain_scores_gemma":[0.9999015,0.0000199989,0.000022766,0.000007237433,0.00002160641,0.00002683386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007941695,0.0004463047,0.0001978832,0.0002573972,0.00003141234,0.000219375,0.00007776231,0.0008418153,0.9878158,0.0002329323,0.000174474,0.00891064],"study_design_scores_gemma":[0.0003657602,0.02032088,0.003240801,0.00007146164,0.0001704499,0.0007029535,0.0001332531,0.002190601,0.9611925,0.0001089165,0.01146725,0.00003515304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876385,0.007197748,0.001301237,0.0001762406,0.00007121552,0.0001796796,0.0003954273,0.00005625043,0.00298366],"genre_scores_gemma":[0.9865069,0.007745297,0.002594077,0.00009661895,0.00002129604,0.00009601428,0.0004642281,0.0000149402,0.002460524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001446664,"threshold_uncertainty_score":0.004839599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165331461700294,"score_gpt":0.2949916990070653,"score_spread":0.2733383843900624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}