{"id":"W2909764694","doi":"10.1002/cbin.11100","title":"IL‐1β functionally attenuates ABCG2 and PDZK1 expression in HK‐2 cells partially through NF‐ĸB activation","year":2019,"lang":"en","type":"article","venue":"Cell Biology International","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China; McGill University","keywords":"Hyperuricemia; Abcg2; Reabsorption; Inflammation; Gout; Chemistry; Transporter; Endocrinology; Symporter; Internal medicine; NF-κB; Cell biology; Western blot; Pharmacology; Uric acid; Biology; Kidney; Medicine; Biochemistry; ATP-binding cassette transporter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002864611,0.000559728,0.0007105651,0.0002432836,0.0002296107,0.0004552159,0.0002276792,0.0003615303,0.001919629],"category_scores_gemma":[0.000127291,0.0002529819,0.0006457622,0.0002674076,0.0004073234,0.0003628579,0.0002271187,0.001278133,0.000496991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002821578,"about_ca_system_score_gemma":0.0003168173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008935623,"about_ca_topic_score_gemma":0.0009042102,"domain_scores_codex":[0.9996388,0.00005600741,0.0000490858,0.00006039828,0.00008768425,0.000108016],"domain_scores_gemma":[0.9998965,0.00001611588,0.00003025368,0.00001538129,0.00001744014,0.00002434547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008369814,0.0001522118,0.0003412704,0.0002259052,0.00002760581,0.0000705687,0.0000585342,0.00008496759,0.9967799,0.0001081929,0.0001278952,0.001186044],"study_design_scores_gemma":[0.0002021288,0.000859078,0.007803438,0.00001641369,0.00007283834,0.00026729,0.0001187392,0.00194859,0.9840389,0.0001000995,0.004560138,0.00001228651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855621,0.007006746,0.004069646,0.0006347828,0.0002439491,0.00005068267,0.0008280139,0.0002046653,0.001399491],"genre_scores_gemma":[0.989764,0.002973516,0.002236912,0.000234943,0.00005751967,0.0001414735,0.001412123,0.00002714274,0.003152362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001919629,"threshold_uncertainty_score":0.006421804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120445621149059,"score_gpt":0.2569123321881141,"score_spread":0.2448677700732082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}