{"id":"W2909790980","doi":"10.1038/s41421-018-0071-9","title":"The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system","year":2019,"lang":"en","type":"article","venue":"Cell Discovery","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Government of Canada; Ottawa Hospital Research Institute; Canadian Institutes of Health Research; University of Ottawa; Muscular Dystrophy Association","keywords":"Proteostasis; Ubiquitin; Chemistry; Biology; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000244529,0.000494981,0.0003788881,0.0003677026,0.000460251,0.0005956015,0.0002958479,0.000260525,0.00062259],"category_scores_gemma":[0.000183115,0.0001657111,0.0003309904,0.00027607,0.0001894708,0.0004293625,0.0005308085,0.0004740615,0.0003711683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006682159,"about_ca_system_score_gemma":0.0002983186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007247007,"about_ca_topic_score_gemma":0.0009043864,"domain_scores_codex":[0.9997095,0.00003601594,0.00002624845,0.00007905682,0.0000813895,0.00006772195],"domain_scores_gemma":[0.9998147,0.00001097509,0.00006378633,0.00002661501,0.00003487654,0.00004902716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008760256,0.00001303615,0.001161733,0.00003923718,0.00001656864,0.00009364662,0.00001343884,0.0001139837,0.9950472,0.0001775364,0.00005138365,0.003184644],"study_design_scores_gemma":[0.000009927021,0.0001120152,0.0212133,0.000008384419,0.00002726557,0.0006458434,0.00003936189,0.003360591,0.9704423,0.0001488585,0.003977615,0.00001447667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886768,0.004567132,0.005380645,0.0001206279,0.00001789153,0.00001986187,0.0002105318,0.0001015791,0.0009049577],"genre_scores_gemma":[0.9947075,0.0007272303,0.002939546,0.00003302444,0.00000746701,0.00001488323,0.0002416077,0.00001396448,0.001314749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007247007,"threshold_uncertainty_score":0.004848242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00864399713381871,"score_gpt":0.217693681944578,"score_spread":0.2090496848107593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}