{"id":"W2909790980","doi":"10.1038/s41421-018-0071-9","title":"The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system","year":2019,"lang":"en","type":"article","venue":"Cell Discovery","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Government of Canada; Ottawa Hospital Research Institute; Canadian Institutes of Health Research; University of Ottawa; Muscular Dystrophy Association","keywords":"Proteostasis; Ubiquitin; Chemistry; Biology; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002366122,0.0001946736,0.000132662,0.00001246059,0.0003633884,0.0001857504,0.0003461961,0.00006750394,0.00002116663],"category_scores_gemma":[0.0000285172,0.00009887484,0.000131873,0.00009081676,0.0001172258,0.00002214995,0.0001661385,0.0001894674,0.0001218518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003174406,"about_ca_system_score_gemma":0.00009952182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006605247,"about_ca_topic_score_gemma":0.0001879915,"domain_scores_codex":[0.9988514,0.0001605076,0.000168005,0.0003355856,0.0001612908,0.0003232332],"domain_scores_gemma":[0.9989652,0.00009495664,0.0001297366,0.000707373,0.00005849204,0.00004426744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009461948,0.0001924812,0.002378509,0.0002905938,0.0003366397,0.00002163869,0.0007564103,0.0003896194,0.9779911,0.006084389,0.009443367,0.001169071],"study_design_scores_gemma":[0.0005400623,0.0002546255,0.0002074103,0.00004257274,0.00004327904,0.00003415447,0.004928837,0.00009400002,0.7848927,0.00002811496,0.2087197,0.0002144459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705865,0.0007569699,0.003476823,0.0006832628,0.0002705934,0.001245954,0.00009556096,0.000028742,0.02285555],"genre_scores_gemma":[0.9886768,0.00006300143,0.0001875325,0.0003291024,0.0002073752,0.0002817703,0.00007464323,0.00003455518,0.01014517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1992764,"threshold_uncertainty_score":0.4031999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00864399713381871,"score_gpt":0.217693681944578,"score_spread":0.2090496848107593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}