{"id":"W2909799277","doi":"10.1016/j.cell.2018.12.012","title":"Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":258,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; Multiple Sclerosis Society; Dana-Farber Cancer Institute; National Multiple Sclerosis Society; European Molecular Biology Organization; National Institute of Environmental Health Sciences; American Cancer Society","keywords":"Biology; Astrocyte; Zebrafish; Inflammation; Experimental autoimmune encephalomyelitis; Neurodegeneration; CRISPR; Computational biology; Immunology; Bioinformatics; Genetics; Neuroscience; Gene; Central nervous system; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00007442434,0.00006513407,0.0001366354,0.00006311916,0.00001228957,0.000002020625,0.00006720387,0.00008271178,0.001249084],"category_scores_gemma":[0.000004371355,0.00006055691,0.00004615915,0.00001690578,0.00005116684,0.00005405269,0.00002094474,0.00009922118,0.000794076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002611845,"about_ca_system_score_gemma":0.00001504934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007188016,"about_ca_topic_score_gemma":0.000002265738,"domain_scores_codex":[0.9995261,0.0001067719,0.0001459677,0.00008347326,0.00001332869,0.0001242878],"domain_scores_gemma":[0.9997542,0.00006313404,0.00006348677,0.0001128309,0.000002557565,0.000003782014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004514676,0.00004228279,0.004542141,0.000009926043,0.00001385225,5.361748e-7,0.0003098272,0.000009008813,0.9932922,0.00002337979,0.00002226836,0.001283078],"study_design_scores_gemma":[0.001692735,0.0001912353,0.02848216,0.00001090002,0.000005933131,0.000004463687,0.0005314323,0.000007746682,0.9638515,0.000003944597,0.005160892,0.00005711822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968262,0.0008962209,0.0000440046,0.00001138112,0.0001896359,0.000132198,0.0000179985,0.000006956209,0.001875364],"genre_scores_gemma":[0.9948144,0.00003365925,0.000005336969,0.00001619087,0.000004921572,0.000005230969,0.00001964807,0.000005437589,0.005095186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0294408,"threshold_uncertainty_score":0.9999839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003501348576963342,"score_gpt":0.1796480553752617,"score_spread":0.1761467067982984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}